High-throughput and single-cell T cell receptor sequencing technologies
T cells express T cell receptors (TCRs) composed of somatically recombined TCRα and
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …
Computational approaches to therapeutic antibody design: established methods and emerging trends
Antibodies are proteins that recognize the molecular surfaces of potentially noxious
molecules to mount an adaptive immune response or, in the case of autoimmune diseases …
molecules to mount an adaptive immune response or, in the case of autoimmune diseases …
Observed Antibody Space: A diverse database of cleaned, annotated, and translated unpaired and paired antibody sequences
The antibody repertoires of individuals and groups have been used to explore disease
states, understand vaccine responses, and drive therapeutic development. The arrival of B …
states, understand vaccine responses, and drive therapeutic development. The arrival of B …
VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium
Here, we report an update of the VDJdb database with a substantial increase in the number
of T-cell receptor (TCR) sequences and their cognate antigens. The update further provides …
of T-cell receptor (TCR) sequences and their cognate antigens. The update further provides …
[HTML][HTML] SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T cell receptors
Understanding the hallmarks of the immune response to SARS-CoV-2 is critical for fighting
the COVID-19 pandemic. We assessed antibody and T cell reactivity in convalescent COVID …
the COVID-19 pandemic. We assessed antibody and T cell reactivity in convalescent COVID …
Dandelion uses the single-cell adaptive immune receptor repertoire to explore lymphocyte developmental origins
Assessment of single-cell gene expression (single-cell RNA sequencing) and adaptive
immune receptor (AIR) sequencing (scVDJ-seq) has been invaluable in studying …
immune receptor (AIR) sequencing (scVDJ-seq) has been invaluable in studying …
Adaptive immune receptor repertoire analysis
B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
Benchmarking of T cell receptor repertoire profiling methods reveals large systematic biases
Monitoring the T cell receptor (TCR) repertoire in health and disease can provide key
insights into adaptive immune responses, but the accuracy of current TCR sequencing …
insights into adaptive immune responses, but the accuracy of current TCR sequencing …
Observed antibody space: a resource for data mining next-generation sequencing of antibody repertoires
Abs are immune system proteins that recognize noxious molecules for elimination. Their
sequence diversity and binding versatility have made Abs the primary class of …
sequence diversity and binding versatility have made Abs the primary class of …
Peripheral immune-based biomarkers in cancer immunotherapy: can we realize their predictive potential?
AB Nixon, KA Schalper, I Jacobs, S Potluri… - … for immunotherapy of …, 2019 - Springer
The immunologic landscape of the host and tumor play key roles in determining how
patients will benefit from immunotherapy, and a better understanding of these factors could …
patients will benefit from immunotherapy, and a better understanding of these factors could …