Hsp90 is a highly abundant and ubiquitous molecular chaperone which plays an essential
role in many cellular processes including cell cycle control, cell survival, hormone and other …

A chiral CpxRhIII catalyst system in situ generated from a CpxRhI (cod) precatalyst and bis
(o‐toluoyl) peroxide as activating oxidant was developed for a C− H activation/ring‐opening …

The molecular chaperone Hsp90 has been found to be essential for viability in all tested
eukaryotes, from the budding yeast to Drosophila. In mammals, two genes encode the two …

Pochonia chlamydosporia is a worldwide-distributed soil fungus with a great capacity to
infect and destroy the eggs and kill females of plant-parasitic nematodes. Additionally, it has …

Resorcylic acid lactones are fungal polyketides that display diverse biological activities, with
the potent Hsp90 inhibitor radicicol being an important representative member. Two fungal …

There is growing interest within the pharmaceutical community to undertake biological
targets that involve protein− protein 1 and, in general, biomacromolecular interactions 2 (PPI …

1.1. Fragments. The central idea in fragment-based discovery is that screening a target
against a small number (as few as 500 compounds) of low molecular weight compounds …

In the past four years, the ATP-dependent heat-shock protein 90 has remained the focus of
much interest. Phase I and phase II anticancer clinical trials with first-generation inhibitors …

Resorcylic acid lactones (RALs) are naturally occurring 14-membered macrolactones that
constitute a class of polyketides derived from fungal metabolites and that possess significant …

Natural products have been fundamental in the development of new therapeutic agents
predicated on the inhibition of heat shock protein 90 (Hsp90). This Perspective describes the …