Copper-catalyzed synthesis of pyrazolo[1,5-a]pyrimidine based triazole-linked glycohybrids: mechanistic insights and bio-applications
Hybrid molecules maintain their stronghold in the drug market, with over 60% of drug
candidates in pharmaceutical industries. The substantial expenses for develo** and …
candidates in pharmaceutical industries. The substantial expenses for develo** and …
Synthesis of triazole bridged N-glycosides of pyrazolo [1, 5-a] pyrimidinones as anticancer agents and their in silico docking studies
In the pursuit of novel therapeutic agents, we present a comprehensive study on the design,
synthesis, and evaluation of a diverse library of triazole bridged N-glycosides of pyrazolo [1 …
synthesis, and evaluation of a diverse library of triazole bridged N-glycosides of pyrazolo [1 …
Novel Abietane Type Sugar Triazole Hybrids and Amides against SARS‐CoV‐2 Spike Glycoprotein and Influenza A Virus
E Tretyakova, L Hua, A Smirnova… - Asian Journal of …, 2024 - Wiley Online Library
Abstract Abietane type diterpenic (dehydroabietic, 2, 3‐dihydroquinopimaric and
maleopimaric) acids were converted by the acid chloride method into a series of aliphatic …
maleopimaric) acids were converted by the acid chloride method into a series of aliphatic …
Molecular Design, synthesis and anticancer activity of novel Pyrazolo [3, 4-b] pyridine-based glycohybrid molecules
Molecular hybridization is an emerging strategy in medicinal chemistry for designing new
bioactive molecules that link pharmacophores covalently and shows synergistic enhanced …
bioactive molecules that link pharmacophores covalently and shows synergistic enhanced …
Efficient synthesis of indole-chalcones based glycohybrids and their anticancer activity
Indole based glycosides belong to the class of pharmacologically active molecules and
found in diverse natural compounds. Herein, we report synthesis of 1, 2, 3-triazole bridged …
found in diverse natural compounds. Herein, we report synthesis of 1, 2, 3-triazole bridged …
Synthesis, Molecular Docking and Anticancer Activity of New Substituted Pyridine-1, 2, 3-Triazole Hybrid N-glycosides Via Click Chemistry
NSA Al-Sahaly, S Alghannay, K Aouadi… - Egyptian Journal of …, 2024 - journals.ekb.eg
Cancer is still the most upsetting threat for human life and its fighting strategies have
acquired intensive research. The design and synthesis of novel candidates for their possible …
acquired intensive research. The design and synthesis of novel candidates for their possible …
Recent Advances Related to Anomeric and Exo-anomeric Effects in Carbohydrate Chemistry
JJR Freitas, PRS Neto, FAM Souza… - … Research Journal of …, 2023 - stm.e4journal.com
The anomeric effect in carbohydrate chemistry is known as the interaction between the OHd
substituent at the anomeric position to favor an axial orientation rather than an equatorial …
substituent at the anomeric position to favor an axial orientation rather than an equatorial …
Pyrimidine-1, 2, 3-Triazole Hybrid Glycosides: Click Based Synthesis and Biological aspects
ELB Mohamed - Journal of Qassim University for Science, 2024 - jnsm.qu.edu.sa
Application of click chemistry for the construction of hybrid structure incorporating 1, 2, 3-
triazole nucleus was extensively studied as a powerful strategy for designing a variety of …
triazole nucleus was extensively studied as a powerful strategy for designing a variety of …