Copper-catalyzed synthesis of pyrazolo[1,5-a]pyrimidine based triazole-linked glycohybrids: mechanistic insights and bio-applications

G Tiwari, A Khanna, R Tyagi, VK Mishra… - Scientific Reports, 2024 - nature.com
Hybrid molecules maintain their stronghold in the drug market, with over 60% of drug
candidates in pharmaceutical industries. The substantial expenses for develo** and …

Synthesis of triazole bridged N-glycosides of pyrazolo [1, 5-a] pyrimidinones as anticancer agents and their in silico docking studies

G Tiwari, VK Mishra, P Kumari, A Khanna, S Sharma… - RSC …, 2024 - pubs.rsc.org
In the pursuit of novel therapeutic agents, we present a comprehensive study on the design,
synthesis, and evaluation of a diverse library of triazole bridged N-glycosides of pyrazolo [1 …

Novel Abietane Type Sugar Triazole Hybrids and Amides against SARS‐CoV‐2 Spike Glycoprotein and Influenza A Virus

E Tretyakova, L Hua, A Smirnova… - Asian Journal of …, 2024 - Wiley Online Library
Abstract Abietane type diterpenic (dehydroabietic, 2, 3‐dihydroquinopimaric and
maleopimaric) acids were converted by the acid chloride method into a series of aliphatic …

Molecular Design, synthesis and anticancer activity of novel Pyrazolo [3, 4-b] pyridine-based glycohybrid molecules

N Verma, G Tiwari, A Khanna, VK Mishra, Y Yadav… - Bioorganic …, 2025 - Elsevier
Molecular hybridization is an emerging strategy in medicinal chemistry for designing new
bioactive molecules that link pharmacophores covalently and shows synergistic enhanced …

Efficient synthesis of indole-chalcones based glycohybrids and their anticancer activity

R Tyagi, K Yadav, A Khanna, SK Mishra… - Bioorganic & Medicinal …, 2024 - Elsevier
Indole based glycosides belong to the class of pharmacologically active molecules and
found in diverse natural compounds. Herein, we report synthesis of 1, 2, 3-triazole bridged …

Synthesis, Molecular Docking and Anticancer Activity of New Substituted Pyridine-1, 2, 3-Triazole Hybrid N-glycosides Via Click Chemistry

NSA Al-Sahaly, S Alghannay, K Aouadi… - Egyptian Journal of …, 2024 - journals.ekb.eg
Cancer is still the most upsetting threat for human life and its fighting strategies have
acquired intensive research. The design and synthesis of novel candidates for their possible …

Recent Advances Related to Anomeric and Exo-anomeric Effects in Carbohydrate Chemistry

JJR Freitas, PRS Neto, FAM Souza… - … Research Journal of …, 2023 - stm.e4journal.com
The anomeric effect in carbohydrate chemistry is known as the interaction between the OHd
substituent at the anomeric position to favor an axial orientation rather than an equatorial …

Pyrimidine-1, 2, 3-Triazole Hybrid Glycosides: Click Based Synthesis and Biological aspects

ELB Mohamed - Journal of Qassim University for Science, 2024 - jnsm.qu.edu.sa
Application of click chemistry for the construction of hybrid structure incorporating 1, 2, 3-
triazole nucleus was extensively studied as a powerful strategy for designing a variety of …