Yeast surface display system: strategies for improvement and biotechnological applications
KV Teymennet-Ramírez, F Martínez-Morales… - … in Bioengineering and …, 2022 - frontiersin.org
Yeast surface display (YSD) is a “whole-cell” platform used for the heterologous expression
of proteins immobilized on the yeast's cell surface. YSD combines the advantages …
of proteins immobilized on the yeast's cell surface. YSD combines the advantages …
An overview on display systems (phage, bacterial, and yeast display) for production of anticancer antibodies; advantages and disadvantages
Antibodies as ideal therapeutic and diagnostic molecules are among the top-selling drugs
providing considerable efficacy in disease treatment, especially in cancer therapy …
providing considerable efficacy in disease treatment, especially in cancer therapy …
Maximizing response to intratumoral immunotherapy in mice by tuning local retention
Direct injection of therapies into tumors has emerged as an administration route capable of
achieving high local drug exposure and strong anti-tumor response. A diverse array of …
achieving high local drug exposure and strong anti-tumor response. A diverse array of …
Tumor-targeting peptides from combinatorial libraries
Cancer is one of the major and leading causes of death worldwide. Two of the greatest
challenges in fighting cancer are early detection and effective treatments with no or …
challenges in fighting cancer are early detection and effective treatments with no or …
Evolving a peptide: library platforms and diversification strategies
K Bozovičar, T Bratkovič - International journal of molecular sciences, 2019 - mdpi.com
Peptides are widely used in pharmaceutical industry as active pharmaceutical ingredients,
versatile tools in drug discovery, and for drug delivery. They find themselves at the …
versatile tools in drug discovery, and for drug delivery. They find themselves at the …
[HTML][HTML] The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design
Summary Interleukin-22 (IL-22) acts on epithelial cells to promote tissue protection and
regeneration, but can also elicit pro-inflammatory effects, contributing to disease pathology …
regeneration, but can also elicit pro-inflammatory effects, contributing to disease pathology …
Activity-based directed evolution of a membrane editor in mammalian cells
Cellular membranes contain numerous lipid species, and efforts to understand the biological
functions of individual lipids have been stymied by a lack of approaches for controlled …
functions of individual lipids have been stymied by a lack of approaches for controlled …
Intranasal gene therapy to prevent infection by SARS-CoV-2 variants
JJ Sims, JA Greig, KT Michalson, S Lian… - PLoS …, 2021 - journals.plos.org
SARS-CoV-2 variants have emerged with enhanced pathogenicity and transmissibility, and
escape from pre-existing immunity, suggesting first-generation vaccines and monoclonal …
escape from pre-existing immunity, suggesting first-generation vaccines and monoclonal …
Molecular evolution of peptides by yeast surface display technology
S Linciano, S Pluda, A Bacchin, A Angelini - MedChemComm, 2019 - pubs.rsc.org
Genetically encoded peptides possess unique properties, such as a small molecular weight
and ease of synthesis and modification, that make them suitable to a large variety of …
and ease of synthesis and modification, that make them suitable to a large variety of …
Development of high affinity and high specificity inhibitors of matrix metalloproteinase 14 through computational design and directed evolution
Degradation of the extracellular matrices in the human body is controlled by matrix
metalloproteinases (MMPs), a family of more than 20 homologous enzymes. Imbalance in …
metalloproteinases (MMPs), a family of more than 20 homologous enzymes. Imbalance in …