Yeast surface display system: strategies for improvement and biotechnological applications

KV Teymennet-Ramírez, F Martínez-Morales… - … in Bioengineering and …, 2022 - frontiersin.org
Yeast surface display (YSD) is a “whole-cell” platform used for the heterologous expression
of proteins immobilized on the yeast's cell surface. YSD combines the advantages …

An overview on display systems (phage, bacterial, and yeast display) for production of anticancer antibodies; advantages and disadvantages

SZB Mahdavi, F Oroojalian, S Eyvazi, M Hejazi… - International Journal of …, 2022 - Elsevier
Antibodies as ideal therapeutic and diagnostic molecules are among the top-selling drugs
providing considerable efficacy in disease treatment, especially in cancer therapy …

Maximizing response to intratumoral immunotherapy in mice by tuning local retention

N Momin, JR Palmeri, EA Lutz, N Jailkhani… - Nature …, 2022 - nature.com
Direct injection of therapies into tumors has emerged as an administration route capable of
achieving high local drug exposure and strong anti-tumor response. A diverse array of …

Tumor-targeting peptides from combinatorial libraries

R Liu, X Li, W **ao, KS Lam - Advanced drug delivery reviews, 2017 - Elsevier
Cancer is one of the major and leading causes of death worldwide. Two of the greatest
challenges in fighting cancer are early detection and effective treatments with no or …

Evolving a peptide: library platforms and diversification strategies

K Bozovičar, T Bratkovič - International journal of molecular sciences, 2019 - mdpi.com
Peptides are widely used in pharmaceutical industry as active pharmaceutical ingredients,
versatile tools in drug discovery, and for drug delivery. They find themselves at the …

[HTML][HTML] The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design

RA Saxton, LT Henneberg, M Calafiore, L Su, KM Jude… - Immunity, 2021 - cell.com
Summary Interleukin-22 (IL-22) acts on epithelial cells to promote tissue protection and
regeneration, but can also elicit pro-inflammatory effects, contributing to disease pathology …

Activity-based directed evolution of a membrane editor in mammalian cells

R Tei, SR Bagde, JC Fromme, JM Baskin - Nature Chemistry, 2023 - nature.com
Cellular membranes contain numerous lipid species, and efforts to understand the biological
functions of individual lipids have been stymied by a lack of approaches for controlled …

Intranasal gene therapy to prevent infection by SARS-CoV-2 variants

JJ Sims, JA Greig, KT Michalson, S Lian… - PLoS …, 2021 - journals.plos.org
SARS-CoV-2 variants have emerged with enhanced pathogenicity and transmissibility, and
escape from pre-existing immunity, suggesting first-generation vaccines and monoclonal …

Molecular evolution of peptides by yeast surface display technology

S Linciano, S Pluda, A Bacchin, A Angelini - MedChemComm, 2019 - pubs.rsc.org
Genetically encoded peptides possess unique properties, such as a small molecular weight
and ease of synthesis and modification, that make them suitable to a large variety of …

Development of high affinity and high specificity inhibitors of matrix metalloproteinase 14 through computational design and directed evolution

V Arkadash, G Yosef, J Shirian, I Cohen… - Journal of Biological …, 2017 - ASBMB
Degradation of the extracellular matrices in the human body is controlled by matrix
metalloproteinases (MMPs), a family of more than 20 homologous enzymes. Imbalance in …