Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …
public health burden worldwide. The most common form of NCD is metabolic diseases …
Thermogenic adipose tissue in energy regulation and metabolic health
The ability to generate thermogenic fat could be a targeted therapy to thwart obesity and
improve metabolic health. Brown and beige adipocytes are two types of thermogenic fat …
improve metabolic health. Brown and beige adipocytes are two types of thermogenic fat …
Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis
X Huang, X Li, H Shen, Y Zhao, Z Zhou, Y Wang… - Nature …, 2023 - nature.com
Sympathetic innervation is essential for the development of functional beige fat that
maintains body temperature and metabolic homeostasis, yet the molecular mechanisms …
maintains body temperature and metabolic homeostasis, yet the molecular mechanisms …
CRL2APPBP2-mediated TSPYL2 degradation counteracts human mesenchymal stem cell senescence
Cullin-RING E3 ubiquitin ligases (CRLs), the largest family of multi-subunit E3 ubiquitin
ligases in eukaryotic cells, represent core cellular machinery for executing protein …
ligases in eukaryotic cells, represent core cellular machinery for executing protein …
FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation
X Qiao, J Lin, J Shen, Y Chen, L Zheng, H Ren, X Zhao… - Oncogene, 2023 - nature.com
FBXO28 is a member of F-box proteins that are the substrate receptors of SCF (SKP1,
CULLIN1, F-box protein) ubiquitin ligase complexes. Despite the implications of its role in …
CULLIN1, F-box protein) ubiquitin ligase complexes. Despite the implications of its role in …
NEDD8-conjugating enzyme E2s: critical targets for cancer therapy
L Zhou, X Lin, J Zhu, L Zhang, S Chen, H Yang… - Cell Death …, 2023 - nature.com
Abstract NEDD8-conjugating enzymes, E2s, include the well-studied ubiquitin-conjugating
enzyme E2 M (UBE2M) and the poorly characterized ubiquitin-conjugating enzyme E2 F …
enzyme E2 M (UBE2M) and the poorly characterized ubiquitin-conjugating enzyme E2 F …
Vascular smooth muscle cell PRDM16 regulates circadian variation in blood pressure
Disruptions of blood pressure (BP) circadian variation are closely associated with an
increased risk of cardiovascular disease. Thus, gaining insights into the molecular …
increased risk of cardiovascular disease. Thus, gaining insights into the molecular …
Consumption of dietary turmeric promotes fat browning and thermogenesis in association with gut microbiota regulation in high-fat diet-fed mice
C Yang, Y Du, T Zhao, L Zhao, L Liu, L Liu, X Yang - Food & Function, 2024 - pubs.rsc.org
This study was designed to verify the anti-obesity effect of dietary turmeric powder (TP) as a
traditional cooking spice and its underlying mechanism. The HFD-fed C57BL/6J mice were …
traditional cooking spice and its underlying mechanism. The HFD-fed C57BL/6J mice were …
Molecular basis for C-degron recognition by CRL2APPBP2 ubiquitin ligase
S Zhao, D Olmayev-Yaakobov, W Ru… - Proceedings of the …, 2023 - National Acad Sciences
E3 ubiquitin ligases determine the specificity of eukaryotic protein degradation by selective
binding to destabilizing protein motifs, termed degrons, in substrates for ubiquitin-mediated …
binding to destabilizing protein motifs, termed degrons, in substrates for ubiquitin-mediated …
βAR-mTOR-lipin1 pathway mediates PKA-RIIβ deficiency-induced adipose browning
B Wang, Z Hu, L Cui, M Zhao, Z Su, Y Jiang… - …, 2024 - pmc.ncbi.nlm.nih.gov
Background: Enhancing white adipose tissue (WAT) browning combats obesity. The RIIβ
subunit of cAMP-dependent protein kinase (PKA) is primarily expressed in the brain and …
subunit of cAMP-dependent protein kinase (PKA) is primarily expressed in the brain and …