In response to major changes in diagnostic algorithms and the publication of mature results
from various large clinical trials, the European Association of Neuro-Oncology (EANO) …

Genome-wide molecular-profiling studies have revealed the characteristic genetic
alterations and epigenetic profiles associated with different types of gliomas. These …

Many patients with malignant gliomas do not respond to alkylating agent chemotherapy.
Alkylator resistance of glioma cells is mainly mediated by the DNA repair enzyme O 6 …

Purpose To investigate whether radiomic features at MRI improve survival prediction in
patients with glioblastoma multiforme (GBM) when they are integrated with clinical and …

Purpose To evaluate the association of multiparametric and multiregional magnetic
resonance (MR) imaging features with key molecular characteristics in patients with newly …

The DNA repair enzyme O 6-methylguanine-DNA methyltransferase (MGMT) antagonizes
the genotoxic effects of alkylating agents. MGMT promoter methylation is the key mechanism …

Glioblastoma is one of the most lethal human cancers, with poor survival despite surgery,
radiation treatment, and chemotherapy. Advances in the treatment of this type of brain tumor …

Glioblastomas,(grade 4 astrocytomas), are aggressive primary brain tumors characterized
by histopathological heterogeneity. High-resolution sequencing technologies have shown …

Investigation into intratumoral heterogeneity (ITH) of the epigenome is in a formative stage.
The patterns of tumor evolution inferred from epigenetic ITH and genetic ITH are remarkably …

Purpose: Recent studies suggest that temozolomide has activity in neuroendocrine tumors.
Low levels of the DNA repair enzyme, O 6-methylguanine DNA methyltransferase (MGMT) …