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Rational design of antibiotic-free antimicrobial contact lenses: trade-offs between antimicrobial performance and biocompatibility
Q Zhu, J Guan, B Tian, P Wang - Biomaterials Advances, 2024 - Elsevier
Microbial keratitis associated with contact lenses (CLs) wear remains a significant clinical
concern. Antibiotic therapy is the current standard of care. However, the emergence of …
concern. Antibiotic therapy is the current standard of care. However, the emergence of …
Antimicrobial peptide expression at the ocular surface and their therapeutic use in the treatment of microbial keratitis
AH Shannon, SA Adelman, EA Hisey… - Frontiers in …, 2022 - frontiersin.org
Microbial keratitis is a common cause of ocular pain and visual impairment worldwide. The
ocular surface has a relatively paucicellular microbial community, mostly found in the …
ocular surface has a relatively paucicellular microbial community, mostly found in the …
BCLA CLEAR-Contact lens wettability, cleaning, disinfection and interactions with tears
Contact lens materials have undergone significant changes over the past 20 years,
particularly with respect to the introduction of silicone hydrogel materials. Whilst this …
particularly with respect to the introduction of silicone hydrogel materials. Whilst this …
Phosphorylcholine-Based Contact Lenses for Sustained Release of Resveratrol: Design, Antioxidant and Antimicrobial Performances, and In Vivo Behavior
Design of advanced contact lenses (CLs) demands materials that are safe and comfortable
for the wearers and that preserve the normal eye microbiota, avoiding chronic inflammation …
for the wearers and that preserve the normal eye microbiota, avoiding chronic inflammation …
Effect of deposition and protease digestion on the ex vivo activity of antimicrobial peptide-coated contact lenses
A clinical study of antimicrobial contact lenses containing the cationic peptide Mel4 was
conducted. The few adverse events that occurred with this lens occurred on or after 13 …
conducted. The few adverse events that occurred with this lens occurred on or after 13 …
Mitigation of cellular and bacterial adhesion on laser modified poly (2-methacryloyloxyethyl phosphorylcholine)/polydimethylsiloxane surface
Nowadays, using polymers with specific characteristics to coat the surface of a device to
prevent undesired biological responses can represent an optimal strategy for develo** …
prevent undesired biological responses can represent an optimal strategy for develo** …
Antimicrobial Peptidomimetics Prevent the Development of Resistance against Gentamicin and Ciprofloxacin in Staphylococcus and Pseudomonas Bacteria
Bacteria readily acquire resistance to traditional antibiotics, resulting in pan-resistant strains
with no available treatment. Antimicrobial resistance is a global challenge and without the …
with no available treatment. Antimicrobial resistance is a global challenge and without the …
Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis
Bacterial keratitis (BK) is a major cause of corneal blindness globally. This study aimed to
develop a novel class of antimicrobial therapy, based on human-derived hybrid host …
develop a novel class of antimicrobial therapy, based on human-derived hybrid host …
In vitro and in vivo evaluation of implantable bacterial-killing coatings based on host defense peptides and their synthetic mimics
Y Qian, S Deng, X Wu, Y She, R Liu, H Lin - Journal of Materials Science & …, 2021 - Elsevier
Contact-killing antimicrobial coatings based on host defense peptides (HDPs) and their
synthetic mimics have shown potential as powerful tools to combat implant-associated …
synthetic mimics have shown potential as powerful tools to combat implant-associated …
[HTML][HTML] Mel4-coated hyaluronic acid-laden etafilcon A contact lenses: Improved wettability with retained antimicrobial properties
Soft contact lenses are a common mode of vision correction used worldwide. However,
contact lens wearers often experience discomfort and are at risk of develo** microbial …
contact lens wearers often experience discomfort and are at risk of develo** microbial …