Peroxisomes of organisms belonging to the protist group Kinetoplastea, which include
trypanosomatid parasites of the genera Trypanosoma and Leishmania, are unique in …

African trypanosomes are responsible for important diseases of humans and animals in sub-
Saharan Africa. The best-studied species is Trypanosoma brucei, which is characterized by …

The African trypanosome, Trypanosoma brucei, maintains an integral link between cell cycle
regulation and differentiation during its intricate life cycle. Whilst extensive changes in …

Microbial pathogens use environmental cues to trigger the developmental events needed to
infect mammalian hosts or transmit to disease vectors. The parasites causing African …

Kinetoplastids, including the human pathogens Trypanosoma brucei, Trypanosoma cruzi
and Leishmania, are the only known organisms that do not regulate the transcription of …

Developmental events in the life-cycle of the slee** sickness parasite comprise integrated
changes in cell morphology, metabolism, gene expression and signalling pathways. In each …

During their life cycle, trypanosomes must overcome conflicting demands to ensure their
survival and transmission. First, they must evade immunity without overwhelming the host …

African trypanosomes cause devastating disease in sub-Saharan Africa in humans and
livestock. The parasite lives extracellularly within the bloodstream of mammalian hosts and …

African trypanosomes are sustained in the bloodstream of their mammalian hosts by their
extreme capacity for antigenic variation. However, for life cycle progression, trypanosomes …

The mitochondrial F0F1 ATP synthase is an essential multi-subunit protein complex in the
vast majority of eukaryotes but little is known about its composition and role in Trypanosoma …