Cancer and Alzheimer's disease (AD) are characterized by (i) opposing biological
mechanisms,(ii) an inverse correlation between their incidences, and (iii) oxidative stress …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Alzheimer's disease is the most common cause of dementia in elderly people. Research into
Alzheimer's disease therapy has been at least partly successful in terms of develo** …

The neurodegenerative diseases, Alzheimer's disease (AD) and Parkinson's disease (PD),
are age-related disorders characterized by the deposition of abnormal forms of specific …

Copper is an important trace element that is required for essential enzymes. However, due
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …

Significance: Alzheimer disease (AD) is an age-related neurodegenerative disease. AD is
characterized by progressive cognitive impairment. One of the main histopathological …

Late-onset Alzheimer's disease (LOAD) is the most common form of Alzheimer's disease
(AD). However, modeling sporadic LOAD that endogenously captures hallmark neuronal …

Matrix metalloproteinases are versatile endopeptidases with many different functions in the
body in health and disease. In the brain, matrix metalloproteinases are critical for tissue …

Metal ions play an important role in biological processes and in metal homeostasis. Metal
imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer's …

Neurodegeneration is the pathological condition, in which the nervous system or neuron
loses its structure, function, or both, leading to progressive degeneration or the death of …