Polyploidy in liver development, homeostasis and disease

R Donne, M Saroul-Aïnama, P Cordier… - Nature reviews …, 2020 - nature.com
Polyploidy (or whole-genome duplication) is the condition of having more than two basic
sets of chromosomes. Polyploidization is well tolerated in many species and can lead to …

Intrinsic and extrinsic factors affecting microtubule dynamics in normal and cancer cells

F Borys, E Joachimiak, H Krawczyk, H Fabczak - Molecules, 2020 - mdpi.com
Microtubules (MTs), highly dynamic structures composed of α-and β-tubulin heterodimers,
are involved in cell movement and intracellular traffic and are essential for cell division …

An integrative human pan-cancer analysis of cyclin-dependent kinase 1 (CDK1)

X Liu, H Wu, Z Liu - Cancers, 2022 - mdpi.com
Simple Summary Cyclin-dependent kinase 1 (CDK1), one of the key regulators of the G2/M
checkpoint, is expressed in many cells and plays an important role in cell cycle control …

[HTML][HTML] Future prospects for mitosis-targeted antitumor therapies

A Serrano-del Valle, C Reina-Ortiz, A Benedi… - Biochemical …, 2021 - Elsevier
Dysregulation of cell cycle progression is a hallmark of cancer cells. In recent years, efforts
have been devoted to the development of new therapies that target proteins involved in cell …

Heat stress at the bicellular stage inhibits sperm cell development and transport into pollen tubes

X Li, A Bruckmann, T Dresselhaus, K Begcy - Plant Physiology, 2024 - academic.oup.com
For successful double fertilization in flowering plants (angiosperms), pollen tubes deliver 2
nonmotile sperm cells toward female gametes (egg and central cell, respectively) …

[HTML][HTML] The role of Anaphase Promoting Complex activation, inhibition and substrates in cancer development and progression

C VanGenderen, TAA Harkness, TG Arnason - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Abstract The Anaphase Promoting Complex (APC), a multi-subunit ubiquitin ligase,
facilitates mitotic and G1 progression, and is now recognized to play a role in maintaining …