Metastasis is the primary cause of cancer morbidity and mortality. The process involves a
complex interplay between intrinsic tumor cell properties as well as interactions between …

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that regulate the
turnover of extracellular matrix (ECM) components. Gross and La Piere discovered MMPs in …

Cancer metastasis is the major cause of cancer morbidity and mortality, and accounts for
about 90% of cancer deaths. Although cancer survival rate has been significantly improved …

Osteosarcoma (OS) is the most common primary malignancy of bone and patients with
metastatic disease or recurrences continue to have very poor outcomes. Unfortunately, little …

Technological advancements in research on circulating biomarkers from patient derived
blood have enabled a less invasive means of diagnosing non-hematologic cancers …

Metastasis is a crucial hallmark of cancer progression, which involves numerous factors
including the degradation of the extracellular matrix (ECM), the epithelial-to-mesenchymal …

Immune checkpoint regulators such as PD-L1 have become exciting new therapeutic targets
leading to long lasting remissions in patients with advanced malignancies. However, in view …

MicroRNAs (miRNAs) are small non-coding RNAs regulating post-transcriptional gene
expression. They play important roles in many biological processes under physiological or …

Distant metastases harbor unique genomic characteristics not detectable in the
corresponding primary tumor of the same patient and metastases located at different sites …

A two-pronged concept combining photodynamic therapy (PDT) and epithelial–
mesenchymal transition (EMT) blockade in a minimalist nanoplatform was proposed to …