Ewing sarcoma
Ewing sarcoma is the second most frequent bone tumour of childhood and adolescence that
can also arise in soft tissue. Ewing sarcoma is a highly aggressive cancer, with a survival of …
can also arise in soft tissue. Ewing sarcoma is a highly aggressive cancer, with a survival of …
The WNT/ROR pathway in cancer: from signaling to therapeutic intervention
K Menck, S Heinrichs, C Baden, A Bleckmann - Cells, 2021 - mdpi.com
The WNT pathway is one of the major signaling cascades frequently deregulated in human
cancer. While research had initially focused on signal transduction centered on β-catenin as …
cancer. While research had initially focused on signal transduction centered on β-catenin as …
Logic-gated ROR1 chimeric antigen receptor expression rescues T cell-mediated toxicity to normal tissues and enables selective tumor targeting
S Srivastava, AI Salter, D Liggitt, S Yechan-Gunja… - Cancer cell, 2019 - cell.com
Many potential targets for CAR-T cells in solid tumors are expressed in some normal tissues,
raising concern for off-tumor toxicity. Following lymphodepletion, CAR-T cells targeting the …
raising concern for off-tumor toxicity. Following lymphodepletion, CAR-T cells targeting the …
High-level ROR1 associates with accelerated disease progression in chronic lymphocytic leukemia
ROR1 is an oncoembryonic orphan receptor found on chronic lymphocytic leukemia (CLL) B
cells, but not on normal postpartum tissues. ROR1 is a receptor for Wnt5a that may complex …
cells, but not on normal postpartum tissues. ROR1 is a receptor for Wnt5a that may complex …
[HTML][HTML] WNT5A in tumor development and progression: A comprehensive review
The investigation of tumor microenvironment (TME) is essential to better characterize the
complex cellular crosstalk and to identify important immunological phenotypes and …
complex cellular crosstalk and to identify important immunological phenotypes and …
The RTK interactome: overview and perspective on RTK heterointeractions
Receptor tyrosine kinases (RTKs) play important roles in cell growth, motility, differentiation,
and survival. These single-pass membrane proteins are grouped into subfamilies based on …
and survival. These single-pass membrane proteins are grouped into subfamilies based on …
Therapeutic advances in the targeting of ROR1 in hematological cancers
Receptor tyrosine kinases (RTKs) are key cell surface receptors involved in cell
communication and signal transduction, with great importance in cell growth, differentiation …
communication and signal transduction, with great importance in cell growth, differentiation …
VEGFR2 as a target for CAR T cell therapy of Ewing sarcoma
A Englisch, B Altvater, S Kailayangiri… - Pediatric blood & …, 2020 - Wiley Online Library
Background T cells engineered to express chimeric antigen receptors (CARs) are a novel
modality to treat refractory cancers. The development of CAR T cells against Ewing sarcoma …
modality to treat refractory cancers. The development of CAR T cells against Ewing sarcoma …
Identification of a novel SYK/c-MYC/MALAT1 signaling pathway and its potential therapeutic value in Ewing sarcoma
Purpose: Ewing sarcoma (EWS) is a devastating soft tissue sarcoma affecting predominantly
young individuals. Tyrosine kinases (TK) and associated pathways are continuously …
young individuals. Tyrosine kinases (TK) and associated pathways are continuously …
A potent and selective dual inhibitor of AXL and MERTK possesses both immunomodulatory and tumor-targeted activity
J Rios-Doria, M Favata, K Lasky, P Feldman… - Frontiers in …, 2020 - frontiersin.org
TYRO3, AXL, and MERTK constitute the TAM family of receptor tyrosine kinases, which play
important roles in tumor growth, survival, cell adhesion, as well as innate immunity …
important roles in tumor growth, survival, cell adhesion, as well as innate immunity …