Lipoproteins and fatty acids in chronic kidney disease: molecular and metabolic alterations
Chronic kidney disease (CKD) induces modifications in lipid and lipoprotein metabolism and
homeostasis. These modifications can promote, modulate and/or accelerate CKD and …
homeostasis. These modifications can promote, modulate and/or accelerate CKD and …
[HTML][HTML] The therapeutic potential of second and third generation CB1R antagonists
Endocannabinoids acting via CB 1 receptors (CB 1 R) play a critical role in regulating
energy homeostasis, which was the rationale for the pharmaceutical development of CB 1 R …
energy homeostasis, which was the rationale for the pharmaceutical development of CB 1 R …
Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span
INTRODUCTION All body cells rely on blood vessels (BVs) for the provision of oxygen and
other blood-borne substances and, in certain settings, also for the provision of endothelial …
other blood-borne substances and, in certain settings, also for the provision of endothelial …
The link between the mitochondrial fatty acid oxidation derangement and kidney injury
Renal proximal tubular cells are high energy-demanding cells mainly relying on fatty acid
oxidation. In stress conditions, such as transient hypoxia, fatty acid oxidation (FAO) …
oxidation. In stress conditions, such as transient hypoxia, fatty acid oxidation (FAO) …
The contribution of lipotoxicity to diabetic kidney disease
JR Schelling - Cells, 2022 - mdpi.com
Lipotoxicity is a fundamental pathophysiologic mechanism in diabetes and non-alcoholic
fatty liver disease and is now increasingly recognized in diabetic kidney disease (DKD) …
fatty liver disease and is now increasingly recognized in diabetic kidney disease (DKD) …
Geniposide improves diabetic nephropathy by enhancing ULK1-mediated autophagy and reducing oxidative stress through AMPK activation
T Dusabimana, EJ Park, J Je, K Jeong, SP Yun… - International journal of …, 2021 - mdpi.com
Diabetic nephropathy (DN) is a common pathological feature in patients with diabetes and
the leading cause of end-stage renal disease. Although several pharmacological agents …
the leading cause of end-stage renal disease. Although several pharmacological agents …
Metabolic messengers: endocannabinoids
Endocannabinoid signalling is considered one of the most important modulatory systems in
a whole organism. Research has yielded great insight on the mechanisms that link …
a whole organism. Research has yielded great insight on the mechanisms that link …
Multiple endocannabinoid-mediated mechanisms in the regulation of energy homeostasis in brain and peripheral tissues
I Ruiz de Azua, B Lutz - Cellular and molecular life sciences, 2019 - Springer
The endocannabinoid (eCB) system is widely expressed in many central and peripheral
tissues, and is involved in a plethora of physiological processes. Among these, activity of the …
tissues, and is involved in a plethora of physiological processes. Among these, activity of the …
An updated pharmacological insight of resveratrol in the treatment of diabetic nephropathy
KX Li, MJ Ji, HJ Sun - Gene, 2021 - Elsevier
As one of the most common complications of diabetes, nephropathy develops in
approximately 40% of diabetic individuals. Although end stage kidney disease is known as …
approximately 40% of diabetic individuals. Although end stage kidney disease is known as …
Chicoric acid attenuated renal tubular injury in HFD-induced chronic kidney disease mice through the promotion of mitophagy via the Nrf2/PINK/Parkin pathway
X Ding, T Jian, Y Gai, G Niu, Y Liu, X Meng… - Journal of Agricultural …, 2022 - ACS Publications
As the main factor in the pathogenesis of chronic kidney disease (CKD), the excessive
apoptosis of renal tubular epithelial cells (RTECs) and its underlying mechanism of action …
apoptosis of renal tubular epithelial cells (RTECs) and its underlying mechanism of action …