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[HTML][HTML] The therapeutic and prophylactic potential of quercetin against COVID-19: An outlook on the clinical studies, inventive compositions, and patent literature
Quercetin is a phenolic flavonol compound with established antioxidant, anti-inflammatory,
and immuno-stimulant properties. Recent studies demonstrate the potential of quercetin …
and immuno-stimulant properties. Recent studies demonstrate the potential of quercetin …
[HTML][HTML] Fexinidazole for human African trypanosomiasis, the fruit of a successful public-private partnership
After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human
African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history …
African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history …
Synthetic approaches to the new drugs approved during 2021
Each year, new drugs are introduced to the market, representing structures that have affinity
for biological targets implicated in human diseases and conditions. These new chemical …
for biological targets implicated in human diseases and conditions. These new chemical …
The urgent threat of Clostridioides difficile infection: A glimpse of the drugs of the future, with related patents and prospects
Clostridioides difficile infection (CDI) is an urgent threat and unmet medical need. The
current treatments for CDI are not enough to fight the burden of CDI and recurrent CDI (r …
current treatments for CDI are not enough to fight the burden of CDI and recurrent CDI (r …
[HTML][HTML] Selenium and COVID-19: A spotlight on the clinical trials, inventive compositions, and patent literature
MK Alshammari, W Fatima, RA Alraya… - Journal of infection and …, 2022 - Elsevier
Selenium is an indispensable trace element for all living organisms. It is an essential
structural component of several selenium-dependent enzymes, which support the human …
structural component of several selenium-dependent enzymes, which support the human …
Oral brincidofovir therapy for monkeypox outbreak: a focused review on the therapeutic potential, clinical studies, patent literature, and prospects
The monkeypox disease (MPX) outbreak of 2022 has been reported in more than one
hundred countries and is becoming a global concern. Unfortunately, only a few treatments …
hundred countries and is becoming a global concern. Unfortunately, only a few treatments …
Further investigations of nitroheterocyclic compounds as potential antikinetoplastid drug candidates
Due to the lack of specific vaccines, management of the trypanosomatid-caused neglected
tropical diseases (slee** sickness, Chagas disease and leishmaniasis) relies exclusively …
tropical diseases (slee** sickness, Chagas disease and leishmaniasis) relies exclusively …
Design and Synthesis of Novel 3-Nitro-1H-1,2,4-triazole-1,2,3-triazole-1,4-disubstituted Analogs as Promising Antitrypanosomatid Agents: Evaluation of In Vitro …
A series of 28 compounds, 3-nitro-1 H-1, 2, 4-triazole, were synthesized by click-chemistry
with diverse substitution patterns using medicinal chemistry approaches, such as …
with diverse substitution patterns using medicinal chemistry approaches, such as …
Multifunctional organometallic compounds active against infective trypanosomes: Ru (II) Ferrocenyl derivatives with two different bioactive ligands
Human African trypanosomiasis (HAT, slee** sickness) and American trypanosomiasis
(Chagas disease) are endemic zoonotic diseases caused by genomically related …
(Chagas disease) are endemic zoonotic diseases caused by genomically related …
Antitrypanosomal chloronitrobenzamides
Human African trypanosomiasis (HAT), a neglected tropical disease caused by
Trypanosoma brucei gambiense (Tbg) or Trypanosoma brucei rhodesiense (Tbr), remains a …
Trypanosoma brucei gambiense (Tbg) or Trypanosoma brucei rhodesiense (Tbr), remains a …