Potential role of IFN-α in COVID-19 patients and its underlying treatment options

L Yang, J Wang, P Hui, TO Yarovinsky, S Badeti… - Applied microbiology …, 2021 - Springer
Abstract The coronavirus disease (COVID-19) caused by a severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly worldwide. Given that this …

Mutations in the genome of severe acute respiratory syndrome coronavirus 2: implications for COVID-19 severity and progression

AA Al-Qahtani - Journal of International Medical Research, 2022 - journals.sagepub.com
Coronaviridae is a large family of enveloped, positive-strand RNA viruses that has plagued
the world since it was discovered in humans in the 1960s. The recent severe acute …

Genetic justification of COVID‐19 patient outcomes using DERGA, a novel data ensemble refinement greedy algorithm

PG Asteris, AH Gandomi, DJ Armaghani… - Journal of Cellular …, 2024 - Wiley Online Library
Complement inhibition has shown promise in various disorders, including COVID‐19. A
prediction tool including complement genetic variants is vital. This study aims to identify …

SARS-CoV-2 and influenza A virus coinfections in ferrets

Y Huang, AL Skarlupka, H Jang… - Journal of …, 2022 - journals.asm.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and seasonal influenza
viruses are cocirculating in the human population. However, only a few cases of viral …

SARS-CoV-2 mutations and COVID-19 clinical outcome: mutation global frequency dynamics and structural modulation hold the key

R Maurya, P Mishra, A Swaminathan, V Ravi… - Frontiers in cellular …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had an enormous
burden on the healthcare system worldwide as a consequence of its new emerging variants …

Predicting COVID-19 disease severity from SARS-CoV-2 spike protein sequence by mixed effects machine learning

BA Sokhansanj, GL Rosen - Computers in biology and medicine, 2022 - Elsevier
Epidemiological studies show that COVID-19 variants-of-concern, like Delta and Omicron,
pose different risks for severe disease, but they typically lack sequence-level information for …

Association between prognostic factors and the outcomes of patients infected with SARS-CoV-2 harboring multiple spike protein mutations

Gunadi, MS Hakim, H Wibawa, Marcellus… - Scientific Reports, 2021 - nature.com
The outcome of SARS-CoV-2 infection is determined by multiple factors, including the viral,
host genetics, age, and comorbidities. This study investigated the association between …

[HTML][HTML] Interpretable and predictive deep neural network modeling of the SARS-Cov-2 spike protein sequence to predict COVID-19 disease severity

BA Sokhansanj, Z Zhao, GL Rosen - Biology, 2022 - mdpi.com
Simple Summary As COVID-19 shifts from pandemic to endemic, emerging variants may be
more or less virulent. Predicting whether an emerging COVID-19 variant has of high risk of …

Severity of infection with the SARS-CoV-2 B. 1.1. 7 lineage among hospitalized COVID-19 patients in Belgium

N Van Goethem, M Vandromme, H Van Oyen… - PLoS …, 2022 - journals.plos.org
Introduction The pathogenesis of COVID-19 depends on the interplay between host
characteristics, viral characteristics and contextual factors. Here, we compare COVID-19 …

Structure and dynamics of whole-sequence homology model of ORF3a protein of SARS-CoV-2: An insight from microsecond molecular dynamics simulations

S Akter, MJ Islam, MA Ali, M Zakaria Tashrif… - Journal of …, 2024 - Taylor & Francis
The ORF3a is a large accessory protein in severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which plays an important role in virulence and viral replication; especially in …