Bacteria belonging to the genus Streptococcus are the first inhabitants of the oral cavity,
which can be acquired right after birth and thus play an important role in the assembly of the …

Lactic acid bacteria (LAB) are important starter, commensal, or pathogenic microorganisms.
The stress physiology of LAB has been studied in depth for over 2 decades, fueled mostly by …

Background The study of microbiomes using whole-metagenome shotgun sequencing
enables the analysis of uncultivated microbial populations that may have important roles in …

Many bacterial species are represented by a pan-genome, whose genetic repertoire far
outstrips that of any single bacterial genome. Here we investigate how a bacterial pan …

Most bacteria can selectively use substrates from a mixture of different carbon sources. The
presence of preferred carbon sources prevents the expression, and often also the activity, of …

Biological pathways are structured in complex networks of interacting genes. Solving the
architecture of such networks may provide valuable information, such as how …

The phosphoenolpyruvate (PEP): carbohydrate phosphotransferase system (PTS) is found
only in bacteria, where it catalyzes the transport and phosphorylation of numerous …

Genetic interactions identify functional connections between genes and pathways,
establishing gene functions or druggable targets. Here we use CRISPRi–TnSeq, CRISPRi …

Streptococci readily colonize mucosal tissues in the nasopharynx; the respiratory,
gastrointestinal, and genitourinary tracts; and the skin. Each ecological niche presents a …

Streptococcus pneumoniae (pneumococcus) is a leading human respiratory pathogen that
causes a variety of serious mucosal and invasive diseases. D39 is an historically important …