Over the past several decades, significant advances have been made in our understanding
of the basic stages and mechanisms of mammalian brain development. Studies elucidating …

One of the landmark events of the past 25 years in neuroscience research was the
establishment of neural stem cells (NSCs) as a life-long source of neurons and glia, a …

The mammalian cerebral cortex has an unparalleled diversity of cell types, which are
generated during development through a series of temporally orchestrated events that are …

Different functional regions of brain are fundamental for basic neurophysiological activities.
However, the regional specification remains largely unexplored during human brain …

Neuroanatomists have long speculated that expanded primate brains contain an increased
morphological diversity of inhibitory neurons (INs), and recent studies have identified …

The mammalian brain contains many specialized cells that develop from a thin sheet of
neuroepithelial progenitor cells. Single-cell transcriptomics revealed hundreds of …

Here, using further optimized 3D culture that allows highly selective induction and long-term
growth of human ES cell (hESC)-derived cortical neuroepithelium, we demonstrate unique …

Slow, controlled breathing has been used for centuries to promote mental calming, and it is
used clinically to suppress excessive arousal such as panic attacks. However, the …

The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are …

Malformations of cerebral cortical development include a wide range of developmental
disorders that are common causes of neurodevelopmental delay and epilepsy. In addition …