Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …

Systemic inflammation can be triggered by infection, surgery, trauma or burns. During
systemic inflammation, an overshooting immune response induces tissue damage resulting …

Angiopoietins 1–4 (Ang1–4) represent an important family of growth factors, whose activities
are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized …

The glycocalyx is a gel-like layer covering the luminal surface of vascular endothelial cells. It
is comprised of membrane-attached proteoglycans, glycosaminoglycan chains …

Rationale Pre-clinical and autopsy studies have fueled the hypothesis that a dysregulated
vascular endothelium might play a central role in the pathogenesis of ARDS and multi-organ …

The vascular endothelial surface is coated by the glycocalyx, a ubiquitous gel‐like layer
composed of a membrane‐binding domain that contains proteoglycans, glycosaminoglycan …

The endothelial glycocalyx comprises a complex layer of membrane-bound proteoglycans,
secreted glycosaminoglycans, glycoproteins, glycolipids and bound plasma proteins such …

Intravenous fluid therapy is one of the most common interventions in acutely ill patients.
Each day, over 20% of patients in intensive care units (ICUs) receive intravenous fluid …

Background Recent studies have highlighted Coronavirus disease 2019 (COVID-19) as a
multisystemic vascular disease. Up to 60% of the patients suffer from long-term sequelae …

According to the latest Global Burden of Disease Study data, non-communicable diseases in
general and cardiovascular disease (CVD) in particular are the leading cause of premature …