From genome-wide associations to candidate causal variants by statistical fine-map**
Advancing from statistical associations of complex traits with genetic markers to
understanding the functional genetic variants that influence traits is often a complex process …
understanding the functional genetic variants that influence traits is often a complex process …
From GWAS to gene: transcriptome-wide association studies and other methods to functionally understand GWAS discoveries
B Li, MD Ritchie - Frontiers in genetics, 2021 - frontiersin.org
Since their inception, genome-wide association studies (GWAS) have identified more than a
hundred thousand single nucleotide polymorphism (SNP) loci that are associated with …
hundred thousand single nucleotide polymorphism (SNP) loci that are associated with …
On the origin and continuing evolution of SARS-CoV-2
The SARS-CoV-2 epidemic started in late December 2019 in Wuhan, China, and has since
impacted a large portion of China and raised major global concern. Herein, we investigated …
impacted a large portion of China and raised major global concern. Herein, we investigated …
SARS-CoV-2 genomic variations associated with mortality rate of COVID-19
Y Toyoshima, K Nemoto, S Matsumoto… - Journal of human …, 2020 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) outbreak, caused by SARS-CoV-2, has
rapidly expanded to a global pandemic. However, numbers of infected cases, deaths, and …
rapidly expanded to a global pandemic. However, numbers of infected cases, deaths, and …
Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity
AR Harper, A Goel, C Grace, KL Thomson… - Nature …, 2021 - nature.com
Hypertrophic cardiomyopathy (HCM) is a common, serious, genetic heart disorder. Rare
pathogenic variants in sarcomere genes cause HCM, but with unexplained phenotypic …
pathogenic variants in sarcomere genes cause HCM, but with unexplained phenotypic …
PopLDdecay: a fast and effective tool for linkage disequilibrium decay analysis based on variant call format files
Motivation Linkage disequilibrium (LD) decay is of great interest in population genetic
studies. However, no tool is available now to do LD decay analysis from variant call format …
studies. However, no tool is available now to do LD decay analysis from variant call format …
Genomic selection and genetic architecture of agronomic traits during modern rapeseed breeding
J Hu, B Chen, J Zhao, F Zhang, T **e, K Xu, G Gao… - Nature Genetics, 2022 - nature.com
Rapeseed (Brassica napus L.) is an important oil-producing crop for the world. Its
adaptation, yield and quality have been considerably improved in recent decades, but the …
adaptation, yield and quality have been considerably improved in recent decades, but the …
Rewiring of the fruit metabolome in tomato breeding
Humans heavily rely on dozens of domesticated plant species that have been further
improved through intensive breeding. To evaluate how breeding changed the tomato fruit …
improved through intensive breeding. To evaluate how breeding changed the tomato fruit …
A chromosome conformation capture ordered sequence of the barley genome
Cereal grasses of the Triticeae tribe have been the major food source in temperate regions
since the dawn of agriculture. Their large genomes are characterized by a high content of …
since the dawn of agriculture. Their large genomes are characterized by a high content of …
Resequencing of 243 diploid cotton accessions based on an updated A genome identifies the genetic basis of key agronomic traits
The ancestors of Gossypium arboreum and Gossypium herbaceum provided the A
subgenome for the modern cultivated allotetraploid cotton. Here, we upgraded the G …
subgenome for the modern cultivated allotetraploid cotton. Here, we upgraded the G …