Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets
RJ Cox - Organic & biomolecular chemistry, 2007 - pubs.rsc.org
Fungi produce a wide variety of biologically active compounds. Among these, the
polyketides form a large and structurally diverse group. These compounds are synthesised …
polyketides form a large and structurally diverse group. These compounds are synthesised …
[HTML][HTML] Develo** fungal heterologous expression platforms to explore and improve the production of natural products from fungal biodiversity
X Meng, Y Fang, M Ding, Y Zhang, K Jia, Z Li… - Biotechnology …, 2022 - Elsevier
Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …
notably for therapeutic agent development. Genome sequencing revealed that the number …
Navigating the fungal polyketide chemical space: from genes to molecules
The iterative type I polyketide synthases (IPKSs) are central to the biosynthesis of an
enormously diverse array of natural products in fungi. These natural products, known as …
enormously diverse array of natural products in fungi. These natural products, known as …
New insights into the formation of fungal aromatic polyketides
JM Crawford, CA Townsend - Nature Reviews Microbiology, 2010 - nature.com
Fungal aromatic polyketides constitute a large family of bioactive natural products and are
synthesized by the non-reducing group of iterative polyketide synthases (PKSs). Their …
synthesized by the non-reducing group of iterative polyketide synthases (PKSs). Their …
The structural role of the carrier protein–active controller or passive carrier
J Crosby, MP Crump - Natural product reports, 2012 - pubs.rsc.org
Covering: 2007 to 2011. Previous review: Nat. Prod. Rep., 2007, 24, 750 Common to all
FASs, PKSs and NRPSs is a remarkable component, the acyl or peptidyl carrier protein …
FASs, PKSs and NRPSs is a remarkable component, the acyl or peptidyl carrier protein …
Deconstruction of iterative multidomain polyketide synthase function
PksA, which initiates biosynthesis of the environmental carcinogen aflatoxin B1, is one of the
multidomain iterative polyketide synthases (IPKSs), a large, poorly understood family of …
multidomain iterative polyketide synthases (IPKSs), a large, poorly understood family of …
Introduction to polyketide biosynthesis
KJ Weissman - Methods in enzymology, 2009 - Elsevier
Publisher Summary Even among natural product-derived medicines, the polyketides stand
out. The fungal-derived statins are the most successful cardiovascular drugs of all time …
out. The fungal-derived statins are the most successful cardiovascular drugs of all time …
Cyclization of aromatic polyketides from bacteria and fungi
Cyclization of aromatic polyketides from bacteria and fungi - Natural Product Reports (RSC
Publishing) DOI:10.1039/B911518H Royal Society of Chemistry View PDF VersionPrevious …
Publishing) DOI:10.1039/B911518H Royal Society of Chemistry View PDF VersionPrevious …
Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis
Background The antifungal therapy caspofungin is a semi-synthetic derivative of
pneumocandin B 0, a lipohexapeptide produced by the fungus Glarea lozoyensis, and was …
pneumocandin B 0, a lipohexapeptide produced by the fungus Glarea lozoyensis, and was …
A Type II Polyketide Synthase is Responsible for Anthraquinone Biosynthesis in Photorhabdus luminescens
AO Brachmann, SA Joyce, H Jenke‐Kodama… - …, 2007 - Wiley Online Library
Type II polyketide synthases are involved in the biosynthesis of numerous clinically relevant
secondary metabolites with potent antibiotic or anticancer activity. Until recently the only …
secondary metabolites with potent antibiotic or anticancer activity. Until recently the only …