Parkinson's Disease: Cells Succumbing to Lifelong Dopamine-Related Oxidative Stress and Other Bioenergetic Challenges
H Watanabe, JM Dijkstra, T Nagatsu - International Journal of Molecular …, 2024 - mdpi.com
The core pathological event in Parkinson's disease (PD) is the specific dying of dopamine
(DA) neurons of the substantia nigra pars compacta (SNc). The reasons why SNc DA …
(DA) neurons of the substantia nigra pars compacta (SNc). The reasons why SNc DA …
Unraveling the Interplay of Dopamine, Carbon Monoxide, and Heme Oxygenase in Neuromodulation and Cognition
The dopaminergic system plays important roles in neuromodulation, including prominent
roles in complex neurological functions such as cognition, reward, motivation, and memory …
roles in complex neurological functions such as cognition, reward, motivation, and memory …
Early synaptic dysfunction of striatal parvalbumin interneurons in a mouse model of Parkinson's disease
Q He, X Zhang, H Yang, D Wang, Y Shu, X Wang - Iscience, 2024 - cell.com
In Parkinson's disease (PD), the loss of dopaminergic signaling remodels striatal circuits,
causing abnormal network activity. The timing and impact on various striatal cell types …
causing abnormal network activity. The timing and impact on various striatal cell types …
Dopaminergic Dependency of Cholinergic Pallidal Neurons
J López-Niño, M Padilla-Orozco, A Ortega… - Neuroscience, 2023 - Elsevier
We employed the whole-cell patch-clamp method and ChAT-Cre mice to study the
electrophysiological attributes of cholinergic neurons in the external globus pallidus. Most …
electrophysiological attributes of cholinergic neurons in the external globus pallidus. Most …
[HTML][HTML] Moving to a non-dopaminergic approach for the treatment of OFF fluctuations in Parkinson's disease
SH Isaacson, P Jenner - Clinical Parkinsonism & Related Disorders, 2025 - Elsevier
In levodopa treated patients with Parkinson's disease (PD), the standard approach to
managing motor fluctuations is to adjust dopaminergic therapy. However, despite the …
managing motor fluctuations is to adjust dopaminergic therapy. However, despite the …
Amelioration of Motor Performance and Nigrostriatal Dopamine Cell Volume Using a Novel Far-Infrared Ceramic Blanket in an A53T Alpha-Synuclein Transgenic …
We had attended a Parkinson's Disease (PD) patient for a non-healing wound who reported
a marked decrease in his hand tremor and freezing of gait when his wound was exposed to …
a marked decrease in his hand tremor and freezing of gait when his wound was exposed to …
A journey through cannabidiol in Parkinson's disease
E Del-Bel, N Barros-Pereira, RP de Moraes… - International Review of …, 2024 - Elsevier
Parkinson's disease is a chronic neurodegenerative disorder with no known cure
characterized by motor symptoms such as tremors, rigidity, bradykinesia (slowness of …
characterized by motor symptoms such as tremors, rigidity, bradykinesia (slowness of …
[HTML][HTML] Functional activation of dorsal striatum astrocytes improves movement deficits in hemi-parkinsonian mice
Parkinson's disease (PD) is characterized by the degeneration of dopaminergic nigrostriatal
inputs, which causes striatal network dysfunction and leads to pronounced motor deficits …
inputs, which causes striatal network dysfunction and leads to pronounced motor deficits …
Deep brain stimulation for potentiation of underactive basal ganglia pathways in Parkinson's disease
KA Spencer - 2023 - search.proquest.com
Bradykinesia is a hallmark of Parkinson's disease (PD). In PD, inhibitory inputs to the globus
pallidus internus (GPi; via striatum) and subthalamic nucleus (STN; via globus pallidus …
pallidus internus (GPi; via striatum) and subthalamic nucleus (STN; via globus pallidus …