Advances and opportunities in malaria population genomics
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
MalDA, accelerating malaria drug discovery
The Malaria Drug Accelerator (MalDA) is a consortium of 15 leading scientific laboratories.
The aim of MalDA is to improve and accelerate the early antimalarial drug discovery process …
The aim of MalDA is to improve and accelerate the early antimalarial drug discovery process …
PerTurboID, a targeted in situ method reveals the impact of kinase deletion on its local protein environment in the cytoadhesion complex of malaria-causing parasites
Reverse genetics is key to understanding protein function, but the mechanistic connection
between a gene of interest and the observed phenotype is not always clear. Here we …
between a gene of interest and the observed phenotype is not always clear. Here we …
A scalable CRISPR-Cas9 gene editing system facilitates CRISPR screens in the malaria parasite Plasmodium berghei
Many Plasmodium genes remain uncharacterized due to low genetic tractability. Previous
large-scale knockout screens have only been able to target about half of the genome in the …
large-scale knockout screens have only been able to target about half of the genome in the …
Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities
Protein and phosphoinositide kinases have been successfully exploited as drug targets in
various disease areas, principally in oncology. In malaria, several protein kinases are under …
various disease areas, principally in oncology. In malaria, several protein kinases are under …
Pre-erythrocytic vaccines against malaria
Malaria, caused by the protozoan Plasmodium, is a devastating disease with over 200
million new cases reported globally every year. Although immunization is arguably the best …
million new cases reported globally every year. Although immunization is arguably the best …
Moving on: How malaria parasites exit the liver
M Scheiner, PC Burda… - Molecular Microbiology, 2024 - Wiley Online Library
An essential step in the life cycle of malaria parasites is their egress from hepatocytes, which
enables the transition from the asymptomatic liver stage to the pathogenic blood stage of …
enables the transition from the asymptomatic liver stage to the pathogenic blood stage of …
Improvement of CRISPR/Cas9 system by transfecting Cas9-expressing Plasmodium berghei with linear donor template
Malaria is caused by infection with Plasmodium parasites and is a major public health
concern. The CRISPR/Cas9 system is a promising technology, but still has technical …
concern. The CRISPR/Cas9 system is a promising technology, but still has technical …
Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver
B Franke-Fayard, C Marin-Mogollon, FJA Geurten… - npj Vaccines, 2022 - nature.com
Whole-sporozoite (WSp) malaria vaccines induce protective immune responses in animal
malaria models and in humans. A recent clinical trial with a WSp vaccine comprising …
malaria models and in humans. A recent clinical trial with a WSp vaccine comprising …
Current status of experimental models for the study of malaria
Infection by malaria parasites (Plasmodium spp.) remains one of the leading causes of
morbidity and mortality, especially in tropical regions of the world. Despite the availability of …
morbidity and mortality, especially in tropical regions of the world. Despite the availability of …