The βγ-crystallins: Native state stability and pathways to aggregation
The βγ-crystallins are among the most stable and long-lived proteins in the human body.
With increasing age, however, they transform to high molecular weight light-scattering …
With increasing age, however, they transform to high molecular weight light-scattering …
Oxidative stress and antioxidant-based interventional medicine in ophthalmology
The different anatomical compartments of the eye are highly subjected to reactive oxygen
species (ROS) generation due to internal factors, such as metabolic high oxygen …
species (ROS) generation due to internal factors, such as metabolic high oxygen …
Lanosterol disrupts aggregation of human γD-crystallin by binding to the hydrophobic dimerization interface
Cataracts are a leading cause of vision impairment, which stem from the misfolding and
aggregation of crystallins in the eye lens. Despite its prevalence and severity, the detailed …
aggregation of crystallins in the eye lens. Despite its prevalence and severity, the detailed …
Aggregation of Trp> Glu point mutants of human gamma‐D crystallin provides a model for hereditary or UV‐induced cataract
E Serebryany, T Takata, E Erickson… - Protein …, 2016 - Wiley Online Library
Numerous mutations and covalent modifications of the highly abundant, long‐lived
crystallins of the eye lens cause their aggregation leading to progressive opacification of the …
crystallins of the eye lens cause their aggregation leading to progressive opacification of the …
Phototoxicity of environmental radiations in human lens: Revisiting the pathogenesis of UV-induced cataract
The magnitude of cataract pathology is indeed significant as it is the principal cause of
blindness worldwide. Also, the prominence of this concept escalates with the current aging …
blindness worldwide. Also, the prominence of this concept escalates with the current aging …
[HTML][HTML] Reactive cysteine residues in the oxidative dimerization and Cu2+ induced aggregation of human γD-crystallin: Implications for age-related cataract
Cysteine (Cys) residues are major causes of crystallin disulfide formation and aggregation in
aging and cataractous human lenses. We recently found that disulfide linkages are highly …
aging and cataractous human lenses. We recently found that disulfide linkages are highly …
Cataract-prone variants of γD-crystallin populate a conformation with a partially unfolded N-terminal domain under native conditions
S Volz, JR Malone, AJ Guseman… - Proceedings of the …, 2025 - pnas.org
Human γD-crystallin, a monomeric protein abundant in the eye lens nucleus, must remain
stably folded for an individual's entire lifetime to avoid aggregation and protein deposition …
stably folded for an individual's entire lifetime to avoid aggregation and protein deposition …
Emerging β-sheet rich conformations in supercompact huntingtin exon-1 mutant structures
There exists strong correlation between the extended polyglutamines (polyQ) within exon-1
of Huntingtin protein (Htt) and age onset of Huntington's disease (HD); however, the …
of Huntingtin protein (Htt) and age onset of Huntington's disease (HD); however, the …
Amyloid fiber formation in human γD-crystallin induced by UV–B photodamage
γD-Crystallin is an abundant structural protein of the lens that is found in native and modified
forms in cataractous aggregates. We establish that UV–B irradiation of γD-Crystallin leads to …
forms in cataractous aggregates. We establish that UV–B irradiation of γD-Crystallin leads to …
Amyloid β-sheet secondary structure identified in UV-induced cataracts of porcine lenses using 2D IR spectroscopy
Cataracts are formed by the aggregation of crystallin proteins in the eye lens. Many in vitro
studies have established that crystallin proteins precipitate into aggregates that contain …
studies have established that crystallin proteins precipitate into aggregates that contain …