Sex hormones in acquired immunity and autoimmune disease

VR Moulton - Frontiers in immunology, 2018 - frontiersin.org
Women have stronger immune responses to infections and vaccination than men.
Paradoxically, the stronger immune response comes at a steep price, which is the high …

Estrogen receptor signaling in the immune system

B Chakraborty, J Byemerwa, T Krebs, F Lim… - Endocrine …, 2023 - academic.oup.com
The immune system functions in a sexually dimorphic manner, with females exhibiting more
robust immune responses than males. However, how female sex hormones affect immune …

Cellular and molecular pathways of COVID-19 and potential points of therapeutic intervention

JP Hussman - Frontiers in pharmacology, 2020 - frontiersin.org
With the objective of linking early findings relating to the novel SARS-CoV-2 coronavirus
with potentially informative findings from prior research literature and to promote …

Autoimmune disease in women: endocrine transition and risk across the lifespan

MK Desai, RD Brinton - Frontiers in endocrinology, 2019 - frontiersin.org
Women have a higher incidence and prevalence of autoimmune diseases than men, and
85% or more patients of multiple autoimmune diseases are female. Women undergo …

The roles of sex hormones in the course of atopic dermatitis

N Kanda, T Hoashi, H Saeki - International journal of molecular sciences, 2019 - mdpi.com
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by T helper 2 cell
(Th2)-shifted abnormal immunity, skin barrier impairment, and pruritus. The prevalence of …

[HTML][HTML] Therapeutic opportunities in cancer therapy: targeting the p53-MDM2/MDMX interactions

M Munisamy, N Mukherjee, L Thomas… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Ubiquitination is a key enzymatic post-translational modification that influences p53 stability
and function. p53 protein regulates the expression of MDM2 (mouse double-minute 2 …

[HTML][HTML] Sex-tailored pharmacology and COVID-19: Next steps towards appropriateness and health equity

A Spini, V Giudice, V Brancaleone, MG Morgese… - Pharmacological …, 2021 - Elsevier
Making gender bias visible allows to fill the gaps in knowledge and understand health
records and risks of women and men. The coronavirus disease 2019 (COVID-19) pandemic …

Estrogen acts through estrogen receptor-β to promote mannan-induced psoriasis-like skin inflammation

H Wu, L Zeng, J Ou, T Wang, Y Chen… - Frontiers in …, 2022 - frontiersin.org
Sex-bias is more obvious in several autoimmune disorders, but not in psoriasis. However,
estrogen levels fluctuate during puberty, menstrual cycle, pregnancy, and menopause …

Estrogen deprivation and estrogen receptor α antagonism decrease DSS colitis in female mice

A Hjelt, S Anttila, A Wiklund, A Rokka… - Pharmacology …, 2024 - Wiley Online Library
The association of hormonal contraception with increased risk of inflammatory bowel
disease (IBD) observed in females suggests involvement of ovarian hormones, such as …

Selective estrogen receptor modulators in COVID-19: a possible therapeutic option?

A Calderone, F Menichetti, F Santini… - Frontiers in …, 2020 - frontiersin.org
Male and female genders exhibit significant differences in the outcome of infective diseases
caused by several viral pathogens. Along with behavioral or social factors which can affect …