Beta‐cell function in type 2 diabetes (T2DM): Can it be preserved or enhanced?

L Sayyed Kassem, A Rajpal, MV Barreiro… - Journal of …, 2023 - Wiley Online Library
Abstract Type 2 diabetes (T2DM) is a complex metabolic disorder manifested by
hyperglycemia, insulin resistance, and deteriorating beta‐cell function. A way to prevent …

Remission of type 2 diabetes: always more questions, but enough answers for action

A Rothberg, M Lean, B Laferrère - Diabetologia, 2024 - Springer
The concept of type 2 diabetes remission is evolving rapidly, and gaining wide public and
professional interest, following demonstration that with substantial intentional weight loss …

Weight cycling impairs pancreatic insulin secretion but does not perturb whole-body insulin action in mice with diet-induced obesity

NC Winn, MA Cottam, M Bhanot, HL Caslin… - Diabetes, 2022 - Am Diabetes Assoc
In the setting of obesity and insulin resistance, glycemia is controlled in part by β-cell
compensation and subsequent hyperinsulinemia. Weight loss improves glycemia and …

A data-driven computational model for obesity-driven diabetes onset and remission through weight loss

V Yildirim, VM Sheraton, R Brands, L Crielaard, R Quax… - Iscience, 2023 - cell.com
Obesity is a major risk factor for the development of type 2 diabetes (T2D), where a
sustained weight loss may result in T2D remission in individuals with obesity. To design …

High protein diet leads to prediabetes remission and positive changes in incretins and cardiovascular risk factors

FB Stentz, A Mikhael, O Kineish, J Christman… - Nutrition, Metabolism …, 2021 - Elsevier
Abstract Background and aims High Protein diets may be associated with endocrine
responses that favor improved metabolic outcomes. We studied the response to High …

How Could Taxes on Sugary Drinks and Foods Help Reduce the Burden Of Type 2 Diabetes?

A Reyes-García, I Junquera-Badilla, C Batis… - Current diabetes …, 2023 - Springer
Abstract Purpose of Review Taxes on sugary drinks and foods have emerged as a key
strategy to counteract the alarming levels of diabetes worldwide. Added sugar consumption …

Associations of Clusters of Cardiovascular Risk Factors with Insulin Resistance and Β-Cell Functioning in a Working-Age Diabetic-Free Population in Kazakhstan

Y Saruarov, G Nuskabayeva, MZ Gencer… - International Journal of …, 2023 - mdpi.com
Cardiovascular risk factors aggregate in determined individuals. Patients with Type 2
diabetes mellitus (T2DM) have higher cardiovascular This study aimed to investigate …

Physiology Reconfigured: How Does Bariatric Surgery Lead to Diabetes Remission?

VL Albaugh, C Axelrod, KP Belmont… - Endocrinology and …, 2023 - endo.theclinics.com
Type 2 diabetes affects more than 450 million people worldwide 1 and is a leading cause of
death due to increased risk of cardiovascular, liver, and kidney disease, as well as …

Point-Counterpoint Debate: Surgery vs Medical Treatment for the Management of Obesity

PR Schauer, AE Rothberg - The Journal of Clinical …, 2024 - academic.oup.com
Obesity is a chronic, relapsing condition with severe health risks and a huge economic
burden. Effective interventions for severe obesity include bariatric or metabolic surgery and …

Gut-muscle communication links FGF19 levels to the loss of lean muscle mass following rapid weight loss

J Wean, S Baranwal, N Miller, JH Shin… - Diabetes & …, 2024 - Elsevier
Objective Optimal weight loss involves decreasing adipose tissue while preserving lean
muscle mass. Identifying molecular mediators that preserve lean muscle mass is therefore a …