The reconstitution of lost bone is a subject that is germane to many orthopedic conditions
including fractures and non-unions, infection, inflammatory arthritis, osteoporosis …

Clinical studies, as well as in vitro and in vivo experiments have demonstrated that
byproducts from joint replacements induce an inflammatory reaction that can result in …

Implants are widely used for orthopaedic applications such as fixing fractures, repairing non-
unions, obtaining a joint arthrodesis, total joint arthroplasty, spinal reconstruction, and soft …

Aseptic loosening and other wear-related complications are some of the most frequent late
reasons for revision of total knee arthroplasty (TKA). Periprosthetic osteolysis (PPOL) pre …

The generation of wear debris is an inevitable result of normal usage of joint replacements.
Wear debris particles stimulate local and systemic biological reactions resulting in chronic …

Currently, younger, more active patients are being offered total joint replacement (TJR) for
end-stage arthritic disorders. Despite improved durability of TJRs, particle-associated wear …

All of the over 1 million total joint replacements implanted in the US each year are expected
to eventually fail after 15–25 years of use, due to slow progressive subtle inflammation at the …

Pathological assessment of periprosthetic tissues is important, not only for diagnosis, but
also for understanding the pathobiology of implant failure. The host response to wear …

Novel evidence‐based prosthetic designs and biomaterials facilitate the performance of
highly successful joint replacement (JR) procedures. To achieve this goal, constructs must …

Despite the success in returning people to health saving mobility and high quality of life, the
over 1 million total joint replacements implanted in the US each year are expected to …