Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond
Traditional antidepressants require many weeks to reveal their therapeutic effects. However,
the widely replicated observation that a single subanesthetic dose of the N-methyl-D …
the widely replicated observation that a single subanesthetic dose of the N-methyl-D …
Update on neuropharmacological treatments for alcoholism: scientific basis and clinical findings
BA Johnson - Biochemical pharmacology, 2008 - Elsevier
The past decade has seen an expansion of research and knowledge on pharmacotherapy
for the treatment of alcohol dependence. The Food and Drug Administration (FDA)-approved …
for the treatment of alcohol dependence. The Food and Drug Administration (FDA)-approved …
Dysfunction of reward processing correlates with alcohol craving in detoxified alcoholics
OBJECTIVE: Alcohol dependence may be associated with dysfunction of mesolimbic
circuitry, such that anticipation of nonalcoholic reward fails to activate the ventral striatum …
circuitry, such that anticipation of nonalcoholic reward fails to activate the ventral striatum …
Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses …
Background In healthy individuals, ketamine hydrochloride and amphetamine sulfate
produce cognitive, behavioral, and subjective effects resembling endogenous psychoses …
produce cognitive, behavioral, and subjective effects resembling endogenous psychoses …
Ketamine and the next generation of antidepressants with a rapid onset of action
R Machado-Vieira, G Salvadore… - Pharmacology & …, 2009 - Elsevier
Existing treatments for major depressive disorder (MDD) usually take weeks to months to
achieve their antidepressant effects, and a significant number of patients do not have …
achieve their antidepressant effects, and a significant number of patients do not have …
Glutamatergic modulators: the future of treating mood disorders?
Mood disorders such as bipolar disorder and major depressive disorder are common,
chronic, and recurrent conditions affecting millions of individuals worldwide. Existing …
chronic, and recurrent conditions affecting millions of individuals worldwide. Existing …
Therapeutic mechanisms of ketamine
Sažetak Major depressive disorder is the greatest burden of developed countries in the
context of morbidity caused by mental disorders. Until recent, ketamine has been mostly …
context of morbidity caused by mental disorders. Until recent, ketamine has been mostly …
Psychological effects of ketamine in healthy volunteers: phenomenological study
BackgroundThe psychosis-inducing effect of ketamine is important evidence supporting the
glutamate hypothesis of schizophrenia. However, the symptoms the drug produces have not …
glutamate hypothesis of schizophrenia. However, the symptoms the drug produces have not …
Family history of alcohol dependence and initial antidepressant response to an N-methyl-D-aspartate antagonist
LE Phelps, N Brutsche, JR Moral, DA Luckenbaugh… - Biological …, 2009 - Elsevier
BACKGROUND: A high rate of comorbidity exists between mood disorders and alcohol
dependence. Furthermore, both ketamine, a dissociative anesthetic with a recently …
dependence. Furthermore, both ketamine, a dissociative anesthetic with a recently …
γ-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment
Context Alcohol facilitates γ-aminobutyric acid (GABA) function, and GABA type A (GABA A)
receptor–facilitating agents suppress alcohol withdrawal symptoms. Advances in molecular …
receptor–facilitating agents suppress alcohol withdrawal symptoms. Advances in molecular …