Cancers undergo sequential changes to proton (H+) concentration and sensing that are
consequences of the disease and facilitate its further progression. The impact of protonation …

Dysregulated pH is a common characteristic of cancer cells, as they have an increased
intracellular pH (pHi) and a decreased extracellular pH (pHe) compared with normal cells …

Intense interest in the'Warburg effect'has been revived by the discovery that hypoxia-
inducible factor 1 (HIF1) reprogrammes pyruvate oxidation to lactic acid conversion; lactic …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

The SLC4 family consists of 10 genes (SLC4A1–5; SLC4A7–11). All encode integral
membrane proteins with very similar hydropathy plots—consistent with 10–14 …

Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities
for therapeutic intervention. The acidic microenvironment within a tumour can promote …

A distinguishing phenotype of solid tumors is the presence of an alkaline cellular feature
despite the surrounding acidic microenvironment. This phenotypic characteristic of tumors …

The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …

Precise spatiotemporal regulation of intracellular pH (pH i) is a prerequisite for normal cell
function, and changes in pH i or pericellular pH (pH e) exert important signalling functions. It …