This study investigates the efficacy of NKG2D chimeric antigen receptor (CAR) engineered T
cells in targeting and eliminating stress-induced senescent cells in vitro. Cellular …

Thoracic aortic aneurysms and dissections (TAAD) represent a substantial cause of
morbidity and mortality worldwide. Many individuals presenting with an inherited form of …

Oxidative stress caused by excess ROS often leads to cellular macromolecule damage and
eventually causes various biological catastrophes. Sirt6, a member of the mammalian …

The reversible glycosylation of nuclear and cytoplasmic proteins (O-GlcNAcylation) is
catalyzed by a single enzyme, namely O-GlcNAc transferase (OGT). The mammalian Ogt …

The use of tankyrase inhibitors is essential for capturing livestock embryonic stem cells
(ESC), yet their mechanisms of action remain largely uncharacterized. Previous studies …

Nucleic acid-based systems play important roles in antiviral defense, including CRISPR/Cas
that adopts RNA-guided DNA cleavage to prevent DNA phage infection and RNA …

Background In spite of new treatments, the incidence of type 2 diabetes (T2D) and its
morbidities continue to rise. The key feature of T2D is resistance of adipose tissue and other …

Heterozygous missense mutations in lysyl oxidase (LOX) are associated with thoracic aortic
aneurysms and dissections. To assess how LOX mutations modify protein function and lead …

The accumulation of senescent cells is thought to play a crucial role in aging‐associated
physiological decline and the pathogenesis of various age‐related pathologies. Targeting …

In addition to the canonical role in protein homeostasis, autophagy has recently been found
to be involved in axonal dystrophy and neurodegeneration. Whether autophagy may also be …