A first line of stress defense: small heat shock proteins and their function in protein homeostasis
M Haslbeck, E Vierling - Journal of molecular biology, 2015 - Elsevier
Small heat shock proteins (sHsps) are virtually ubiquitous molecular chaperones that can
prevent the irreversible aggregation of denaturing proteins. sHsps complex with a variety of …
prevent the irreversible aggregation of denaturing proteins. sHsps complex with a variety of …
[HTML][HTML] Small heat shock proteins: role in cellular functions and pathology
Small heat shock proteins (sHsps) are conserved across species and are important in stress
tolerance. Many sHsps exhibit chaperone-like activity in preventing aggregation of target …
tolerance. Many sHsps exhibit chaperone-like activity in preventing aggregation of target …
Small heat shock proteins: Simplicity meets complexity
M Haslbeck, S Weinkauf, J Buchner - Journal of Biological Chemistry, 2019 - ASBMB
Small heat shock proteins (sHsps) are a ubiquitous and ancient family of ATP-independent
molecular chaperones. A key characteristic of sHsps is that they exist in ensembles of iso …
molecular chaperones. A key characteristic of sHsps is that they exist in ensembles of iso …
Small heat shock proteins and α-crystallins: dynamic proteins with flexible functions
E Basha, H O'Neill, E Vierling - Trends in biochemical sciences, 2012 - cell.com
The small heat shock proteins (sHSPs) and the related α-crystallins (αCs) are virtually
ubiquitous proteins that are strongly induced by a variety of stresses, but that also function …
ubiquitous proteins that are strongly induced by a variety of stresses, but that also function …
Atomic view of a toxic amyloid small oligomer
Amyloid diseases, including Alzheimer's, Parkinson's, and the prion conditions, are each
associated with a particular protein in fibrillar form. These amyloid fibrils were long …
associated with a particular protein in fibrillar form. These amyloid fibrils were long …
Protein data bank: a comprehensive review of 3D structure holdings and worldwide utilization by researchers, educators, and students
The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB),
funded by the United States National Science Foundation, National Institutes of Health, and …
funded by the United States National Science Foundation, National Institutes of Health, and …
Large potentials of small heat shock proteins
Modern classification of the family of human small heat shock proteins (the so-called HSPB)
is presented, and the structure and properties of three members of this family are analyzed …
is presented, and the structure and properties of three members of this family are analyzed …
Small heat shock proteins, big impact on protein aggregation in neurodegenerative disease
JM Webster, AL Darling, VN Uversky… - Frontiers in …, 2019 - frontiersin.org
Misfolding, aggregation, and aberrant accumulation of proteins are central components in
the progression of neurodegenerative disease. Cellular molecular chaperone systems …
the progression of neurodegenerative disease. Cellular molecular chaperone systems …
Small heat shock proteins HSP27 (HspB1), αB-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death
J Acunzo, M Katsogiannou, P Rocchi - … journal of biochemistry & cell biology, 2012 - Elsevier
Hsp27, αB-crystallin and HSP22 are ubiquitous small heat shock proteins (sHsp) whose
expression is induced in response to a wide variety of unfavorable physiological and …
expression is induced in response to a wide variety of unfavorable physiological and …
[HTML][HTML] Aging of the eye: Lessons from cataracts and age-related macular degeneration
A Cvekl, J Vijg - Ageing Research Reviews, 2024 - Elsevier
Aging is the greatest risk factor for chronic human diseases, including many eye diseases.
Geroscience aims to understand the effects of the aging process on these diseases …
Geroscience aims to understand the effects of the aging process on these diseases …