Ferroptosis is an iron-dependent form of non-apoptotic cell death characterized by
excessive lipid peroxidation and associated with a plethora of pathological conditions in the …

Liver fibrosis, as an excess deposition of extracellular matrix (ECM) components, results
from chronic liver injury as well as persistent activation of inflammatory response and of …

Background & Aims Hepatocellular carcinoma (HCC), a leading cause of cancer-related
death, is associated with viral hepatitis, non-alcoholic steatohepatitis (NASH), and alcohol …

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide,
and therapeutic options for advanced HCC are limited. Here, we observe that intestinal …

Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …

Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that
occurs either as a predictable event when an individual is exposed to toxic doses of some …

It is currently not well known how necroptosis and necroptosis responses manifest in vivo.
Here, we uncovered a molecular switch facilitating reprogramming between two alternative …

The loss of vital cells within healthy tissues contributes to the development, progression and
treatment outcomes of many human disorders, including neurological and infectious …

Hepatocytes, the major parenchymal cells in the liver, are responsible for a variety of cellular
functions including carbohydrate, lipid and protein metabolism, detoxification and immune …

The progression of chronic liver diseases (CLD), irrespective of etiology, involves chronic
parenchymal injury, persistent activation of inflammatory response as well as sustained …