Chemotherapy is one of the most common treatments for cancer that uses one or more anti-
cancer drugs as a part of the standardized chemotherapy regimen. Cytotoxic chemicals …

Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …

Abstract P-glycoprotein (P-gp) is a drug efflux transporter that triggers doxorubicin (DOX)
resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2 …

Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Multidrug resistance (MDR) remains one of the major impediments for efficacious cancer
chemotherapy. Increased efflux of multiple chemotherapeutic drugs by transmembrane ATP …

The blood-brain barrier (BBB) is a dynamic structure that protects the brain from harmful
blood-borne, endogenous and exogenous substances and maintains the homeostatic …

Cancer is a prominent cause of death globally. Currently, many drugs that are in clinical
practice are having a high prevalence of side effect and multidrug resistance. Risk of tumors …

Multidrug resistance (MDR) is a serious phenomenon employed by cancer cells which
hampers the success of cancer pharmacotherapy. One of the common mechanisms of MDR …

Drug resistance has compromised the efficacy of chemotherapy. The dysregulation of drug
transporters including P-glycoprotein (P-gp) can mediate drug resistance through drug …

The presence of multidrug resistance (MDR) in malignant tumors is one of the primary
causes of treatment failure in cancer chemotherapy. The overexpression of the ATP binding …