Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …

The clearance of apoptotic cells by professional and non-professional phagocytes—a
process termed 'efferocytosis'—is essential for the maintenance of tissue homeostasis …

Extracellular vesicles (EVs) are small vesicles released by donor cells that can be taken up
by recipient cells. Despite their discovery decades ago, it has only recently become …

Being deeply connected to signalling, cell dynamics, growth, regulation, and defence,
endocytic processes are linked to almost all aspects of cell life and disease. In this review …

Antigenic peptide-loaded MHC class II molecules (peptide–MHC class II) are constitutively
expressed on the surface of professional antigen-presenting cells (APCs), including …

Macroautophagy (referred to here as autophagy) is induced by starvation to capture and
degrade intracellular proteins and organelles in lysosomes, which recycles intracellular …

Endocytic recycling is coordinated with endocytic uptake to control the composition of the
plasma membrane. Although much of our understanding of endocytic recycling has come …

Collaborative efforts from the fields of biology, materials science, and engineering are
leading to exciting progress in the development of nanomedicines. Since the targets of many …

With more than ten new FDA approvals since 2001, peptides are emerging as an important
therapeutic alternative to small molecules. However, unlike small molecules, peptides on the …

▪ Abstract Endocytosis in eukaryotic cells is characterized by the continuous and regulated
formation of prolific numbers of membrane vesicles at the plasma membrane. These …