Objectives: This article are to describe current trends in the treatment of schizophrenia and
the most interesting new approaches to optimizing outcome and fostering the development …

Exposure to environmental enrichment can beneficially influence the behavior and enhance
synaptic plasticity. The aim of the present study was to investigate the mediated effects of …

Schizophrenia is a severe mental disorder characterized by positive, negative, and cognitive
symptoms. Cognitive symptoms are a kind of symptoms with high incidence and great …

Recent studies have indicated that environmental enrichment (EE) increases the sensorial
and social stimulations and leads to strengthened plastic changes in the brain. In models of …

Synaptic deficit-induced excitation and inhibition (E/I) imbalance have been implicated in the
pathogenesis of schizophrenia. Using in vivo two-photon microscopy, we examined the …

Neonatal administration of MK-801 (NMDA receptor antagonist) results in schizophrenia-like
behaviors in rodents. Berberine (BBR) is a herbal alkaloid, which shows many …

Alzheimer's disease (AD) is associated with a progressive dementia, and there is good
evidence that it is more pronounced in individuals that have fewer stimuli during their lives …

A plethora of studies have indicated that enriched environment (EE) paradigm provokes
plastic and morphological changes in astrocytes with accompanying increments of their …

Background and Purpose Dysregulation of dopaminergic transmission combined with
transient hypofunction of N‐methyl‐d‐aspartate receptors (NMDARs) is a key mechanism …

Schizophrenia is a mental disorder characterized by psychosis, negative symptoms and
cognitive impairment. Cognitive deficits are enduring and represent the most disabling …