Abstract The concept of 1, 3‐dipolar cycloadditions was presented by Rolf Huisgen 60 years
ago. Previously unknown reactive intermediates, for example azomethine ylides, were …

The activation strain or distortion/interaction model is a tool to analyze activation barriers that
determine reaction rates. For bimolecular reactions, the activation energies are the sum of …

The merging of click chemistry with discrete photochemical processes has led to the creation
of a new class of click reactions, collectively known as photoclick chemistry. These light …

Understanding chemical reactivity through the use of state-of-the-art computational
techniques enables chemists to both predict reactivity and rationally design novel reactions …

In his seminal work, 1 Rolf Huisgen defined 1, 3-dipolar cycloadditions as “1, 3-Dipole, abc,
must be defined, such that atom a posseses an electron sextet, that is, an incomplete …

The merger of photoredox and nickel catalysis has enabled the construction of quaternary
centers. However, the mechanism, role of the ligand, and effect of the spin state for this …

The research on 1, 2, 3-triazoles has been lively and ever-growing since its stimulation by
the advent of click chemistry. The attractiveness of 1H-1, 2, 3-triazoles and their derivatives …

In this Tutorial Review, we make the point that a true understanding of trends in reactivity (as
opposed to measuring or simply computing them) requires a causal reactivity model. To this …

The reactivity of metal‐hydride complexes can be harnessed by the modification of ancillary
ligands. With the aim of improving the hydride‐donor ability of the key Mn− H intermediate …

The advancement of polymer science embraces the invention of molecular constructs that
provide functional applications. As a result, the development of novel methodologies for the …