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Haplotype-aware sequence alignment to pangenome graphs
Modern pangenome graphs are built using haplotype-resolved genome assemblies. When
map** reads to a pangenome graph, prioritizing alignments that are consistent with the …
map** reads to a pangenome graph, prioritizing alignments that are consistent with the …
Label-guided seed-chain-extend alignment on annotated De Bruijn graphs
Motivation Exponential growth in sequencing databases has motivated scalable De Bruijn
graph-based (DBG) indexing for searching these data, using annotations to label nodes with …
graph-based (DBG) indexing for searching these data, using annotations to label nodes with …
MetaGraph-MLA: Label-guided alignment to variable-order De Bruijn graphs
The amount of data stored in genomic sequence databases is growing exponentially, far
exceeding traditional indexing strategies' processing capabilities. Many recent indexing …
exceeding traditional indexing strategies' processing capabilities. Many recent indexing …