Incidence, mortality, survival, risk factor and screening of colorectal cancer: A comparison among China, Europe, and northern America
Colorectal cancer (CRC) is one of the most common malignancies worldwide. China,
Europe and northern America account for more than half of the new CRC cases and …
Europe and northern America account for more than half of the new CRC cases and …
Recent insights into nanotechnology in colorectal cancer
Colorectal cancer (CRC) is the third cancer among the known causes of cancer that impact
people. Although CRC drug options are imperfect, primary detection of CRC can play a key …
people. Although CRC drug options are imperfect, primary detection of CRC can play a key …
[HTML][HTML] Delphi initiative for early-onset colorectal cancer (DIRECt) international management guidelines
Background & Aims Patients with early-onset colorectal cancer (eoCRC) are managed
according to guidelines that are not age-specific. A multidisciplinary international group …
according to guidelines that are not age-specific. A multidisciplinary international group …
Polygenic scores in cancer
Since the publication of the first genome-wide association study for cancer in 2007,
thousands of common alleles that are associated with the risk of cancer have been …
thousands of common alleles that are associated with the risk of cancer have been …
Colorectal cancer risk assessment and precision approaches to screening: brave new world or worlds apart?
Current colorectal cancer (CRC) screening recommendations take a “one-size-fits-all”
approach using age as the major criterion to initiate screening. Precision screening that …
approach using age as the major criterion to initiate screening. Precision screening that …
Will polygenic risk scores for cancer ever be clinically useful?
Genome-wide association studies (GWAS) have identified associations between common
genetic variants, single nucleotide polymorphisms (SNPs) and the risk of develo** …
genetic variants, single nucleotide polymorphisms (SNPs) and the risk of develo** …
[HTML][HTML] Early-onset colorectal cancer: Current insights and future directions
CWK Wu, RN Lui - World journal of gastrointestinal oncology, 2022 - ncbi.nlm.nih.gov
Early-onset colorectal cancer (EOCRC) has seen an alarming rise worldwide over the past
two decades. The reason for this global trend is poorly understood. EOCRC appears to have …
two decades. The reason for this global trend is poorly understood. EOCRC appears to have …
Risk assessment for colorectal cancer via polygenic risk score and lifestyle exposure: a large-scale association study of East Asian and European populations
Background The genetic architectures of colorectal cancer are distinct across different
populations. To date, the majority of polygenic risk scores (PRSs) are derived from …
populations. To date, the majority of polygenic risk scores (PRSs) are derived from …
A microRNA panel compared to environmental and polygenic scores for colorectal cancer risk prediction
JR Raut, B Schöttker, B Holleczek, F Guo… - Nature …, 2021 - nature.com
Circulating microRNAs (miRNAs) could improve colorectal cancer (CRC) risk prediction.
Here, we derive a blood-based miRNA panel and evaluate its ability to predict CRC …
Here, we derive a blood-based miRNA panel and evaluate its ability to predict CRC …
Polygenic risk scores, radiation treatment exposures and subsequent cancer risk in childhood cancer survivors
Survivors of childhood cancer are at increased risk for subsequent cancers attributable to
the late effects of radiotherapy and other treatment exposures; thus, further understanding of …
the late effects of radiotherapy and other treatment exposures; thus, further understanding of …