Synovial sarcoma: current concepts and future perspectives
S Stacchiotti, BA Van Tine - Journal of clinical oncology, 2018 - ascopubs.org
Synovial sarcoma (SS) is a rare sarcoma driven by a translocation between SS18 and SSX
1, 2, or 4. With approximately 800 to 1,000 cases a year in the United States, it most …
1, 2, or 4. With approximately 800 to 1,000 cases a year in the United States, it most …
[HTML][HTML] Synovial sarcoma: characteristics, challenges, and evolving therapeutic strategies
Synovial sarcoma (SS) is a rare and aggressive disease that accounts for 5%-10% of all soft
tissue sarcomas. Although it can occur at any age, it typically affects younger adults and …
tissue sarcomas. Although it can occur at any age, it typically affects younger adults and …
A role for SMARCB1 in synovial sarcomagenesis reveals that SS18–SSX induces canonical BAF destruction
J Li, TS Mulvihill, L Li, JJ Barrott, ML Nelson, L Wagner… - Cancer discovery, 2021 - AACR
Reduced protein levels of SMARCB1 (also known as BAF47, INI1, SNF5) have long been
observed in synovial sarcoma. Here, we show that combined Smarcb1 genetic loss with …
observed in synovial sarcoma. Here, we show that combined Smarcb1 genetic loss with …
Afamitresgene autoleucel for advanced synovial sarcoma and myxoid round cell liposarcoma (SPEARHEAD-1): an international, open-label, phase 2 trial
Background Afamitresgene autoleucel (afami-cel) showed acceptable safety and promising
efficacy in a phase 1 trial (NCT03132922). The aim of this study was to further evaluate the …
efficacy in a phase 1 trial (NCT03132922). The aim of this study was to further evaluate the …
Malic enzyme 1 absence in synovial sarcoma shifts antioxidant system dependence and increases sensitivity to ferroptosis induction with ACXT-3102
CB Brashears, BC Prudner, R Rathore… - Clinical Cancer …, 2022 - AACR
Purpose: To investigate the metabolism of synovial sarcoma (SS) and elucidate the effect of
malic enzyme 1 absence on SS redox homeostasis. Experimental Design: ME1 expression …
malic enzyme 1 absence on SS redox homeostasis. Experimental Design: ME1 expression …
The clear cell sarcoma functional genomic landscape
Clear cell sarcoma (CCS) is a deadly malignancy affecting adolescents and young adults. It
is characterized by reciprocal translocations resulting in expression of the chimeric EWSR1 …
is characterized by reciprocal translocations resulting in expression of the chimeric EWSR1 …
Mut2Vec: distributed representation of cancerous mutations
Background Embedding techniques for converting high-dimensional sparse data into low-
dimensional distributed representations have been gaining popularity in various fields of …
dimensional distributed representations have been gaining popularity in various fields of …
The recent advances in molecular diagnosis of soft tissue tumors
JH Choi, JY Ro - International Journal of Molecular Sciences, 2023 - mdpi.com
Soft tissue tumors are rare mesenchymal tumors with divergent differentiation. The diagnosis
of soft tissue tumors is challenging for pathologists owing to the diversity of tumor types and …
of soft tissue tumors is challenging for pathologists owing to the diversity of tumor types and …
Upregulation of ERK-EGR1-heparanase axis by HDAC inhibitors provides targets for rational therapeutic intervention in synovial sarcoma
C Lanzi, E Favini, L Dal Bo, M Tortoreto… - Journal of Experimental …, 2021 - Springer
Background Synovial sarcoma (SS) is an aggressive soft tissue tumor with limited
therapeutic options in advanced stage. SS18-SSX fusion oncogenes, which are the …
therapeutic options in advanced stage. SS18-SSX fusion oncogenes, which are the …
[HTML][HTML] Sarcoma–The standard-bearer in cancer discovery
JW Potter, KB Jones, JJ Barrott - Critical reviews in oncology/hematology, 2018 - Elsevier
Sarcoma is a rare tumor type that occurs most frequently in connective tissue. Despite its
uncommon occurrence, sarcoma research has provided the means for groundbreaking …
uncommon occurrence, sarcoma research has provided the means for groundbreaking …