The use of hyperpolarised 13C-MRI in clinical body imaging to probe cancer metabolism
R Woitek, FA Gallagher - British journal of cancer, 2021 - nature.com
Metabolic reprogramming is one of the hallmarks of cancer and includes the Warburg effect,
which is exhibited by many tumours. This can be exploited by positron emission tomography …
which is exhibited by many tumours. This can be exploited by positron emission tomography …
Current methods for hyperpolarized [1‐13C]pyruvate MRI human studies
Abstract MRI with hyperpolarized (HP) 13C agents, also known as HP 13C MRI, can
measure processes such as localized metabolism that is altered in numerous cancers, liver …
measure processes such as localized metabolism that is altered in numerous cancers, liver …
[HTML][HTML] Deuterium metabolic imaging and hyperpolarized 13C-MRI of the normal human brain at clinical field strength reveals differential cerebral metabolism
Deuterium metabolic imaging (DMI) and hyperpolarized 13 C-pyruvate MRI (13 C-HPMRI)
are two emerging methods for non-invasive and non-ionizing imaging of tissue metabolism …
are two emerging methods for non-invasive and non-ionizing imaging of tissue metabolism …
[HTML][HTML] Hyperpolarized [2–13C] pyruvate MR molecular imaging with whole brain coverage
Abstract Hyperpolarized (HP) 13 C Magnetic Resonance Imaging (MRI) was applied for the
first time to image and quantify the uptake and metabolism of [2–13 C] pyruvate in the …
first time to image and quantify the uptake and metabolism of [2–13 C] pyruvate in the …
Whole‐Abdomen Metabolic Imaging of Healthy Volunteers Using Hyperpolarized [1‐13C]pyruvate MRI
Background Hyperpolarized 13C MRI quantitatively measures enzyme‐catalyzed
metabolism in cancer and metabolic diseases. Whole‐abdomen imaging will permit …
metabolism in cancer and metabolic diseases. Whole‐abdomen imaging will permit …
Quantification of Prostate Cancer Metabolism Using 3D Multiecho bSSFP and Hyperpolarized [1‐13C] Pyruvate: Metabolism Differs Between Tumors of the Same …
Background Three‐dimensional (3D) multiecho balanced steady‐state free precession (ME‐
bSSFP) has previously been demonstrated in preclinical hyperpolarized (HP) 13C‐MRI in …
bSSFP) has previously been demonstrated in preclinical hyperpolarized (HP) 13C‐MRI in …
Hyperpolarised 13C-MRI using 13C-pyruvate in breast cancer: A review
Tumour metabolism can be imaged with a novel imaging technique termed hyperpolarised
carbon-13 (13 C)-MRI using probes, ie, endogenously found molecules that are labeled with …
carbon-13 (13 C)-MRI using probes, ie, endogenously found molecules that are labeled with …
Hyperpolarized Carbon-13 MRI in Breast Cancer
R Woitek, KM Brindle - Diagnostics, 2023 - mdpi.com
One of the hallmarks of cancer is metabolic reprogramming, including high levels of aerobic
glycolysis (the Warburg effect). Pyruvate is a product of glucose metabolism, and 13C-MR …
glycolysis (the Warburg effect). Pyruvate is a product of glucose metabolism, and 13C-MR …
Hyperpolarised [2-13 C]-pyruvate by 13 C SABRE in an acetone/water mixture
Signal Amplification By Reversible Exchange (SABRE) can provide strong signal
enhancement (SE) to an array of molecules through reversible exchange of parahydrogen …
enhancement (SE) to an array of molecules through reversible exchange of parahydrogen …
Specialized computational methods for denoising, B1 correction, and kinetic modeling in hyperpolarized 13C MR EPSI studies of liver tumors
Purpose To develop a novel post‐processing pipeline for hyperpolarized (HP) 13C MRSI
that integrates tensor denoising and correction to measure pyruvate‐to‐lactate conversion …
that integrates tensor denoising and correction to measure pyruvate‐to‐lactate conversion …