Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …

Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Chiral amines are pivotal building blocks for the pharmaceutical industry. Asymmetric
reductive amination is one of the most efficient and atom economic methodologies for the …

Biocatalysis is an effective tool to access chiral molecules that are otherwise hard to
synthesize or purify. Time-efficient processes are needed to develop enzymes that …

Reductions play a key role in organic synthesis, producing chiral products with new
functionalities. Enzymes can catalyse such reactions with exquisite stereo‐, regio‐and …

Imine reductases catalyse the reductive amination of aldehydes or ketones with amines to
produce chiral amines—a key transformation in the preparation of fine chemicals and active …

Imine reductases (IREDs) and reductive aminases (RedAms) are NADPH-dependent
oxidoreductases catalyzing C–N redox reactions. These include the enantioselective …

The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical
fields are interconnected and synergized. A way to depict that innovation is by conducting a …

The trityl-substituted bisoxazoline (TrHBOX) was prepared as a chiral analogue to a
previously reported nickel dipyrrin system capable of ring-closing amination catalysis …

The asymmetric reduction of double bonds using NAD (P) H‐dependent oxidoreductases
has proven to be an efficient tool for the synthesis of important chiral molecules in research …