The global burden of latent tuberculosis infection: a re-estimation using mathematical modelling

RMGJ Houben, PJ Dodd - PLoS medicine, 2016 - journals.plos.org
Background The existing estimate of the global burden of latent TB infection (LTBI) as “one-
third” of the world population is nearly 20 y old. Given the importance of controlling LTBI as …

Heterogeneity in tuberculosis

AM Cadena, SM Fortune, JAL Flynn - Nature Reviews Immunology, 2017 - nature.com
Infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), results
in a range of clinical presentations in humans. Most infections manifest as a clinically …

Revisiting the timetable of tuberculosis

MA Behr, PH Edelstein, L Ramakrishnan - Bmj, 2018 - bmj.com
Revisiting the timetable of tuberculosis Page 1 Revisiting the timetable of tuberculosis OPEN
ACCESS Tuberculosis has a much shorter incubation period than is widely thought, say Marcel …

Of tuberculosis and non-tuberculous mycobacterial infections–a comparative analysis of epidemiology, diagnosis and treatment

R Gopalaswamy, S Shanmugam, R Mondal… - Journal of biomedical …, 2020 - Springer
Pulmonary diseases due to mycobacteria cause significant morbidity and mortality to human
health. In addition to tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), recent …

Gamma interferon release assays for detection of Mycobacterium tuberculosis infection

M Pai, CM Denkinger, SV Kik… - Clinical microbiology …, 2014 - Am Soc Microbiol
Identification and treatment of latent tuberculosis infection (LTBI) can substantially reduce
the risk of develo** active disease. However, there is no diagnostic gold standard for LTBI …

Four-gene pan-African blood signature predicts progression to tuberculosis

S Suliman, EG Thompson, J Sutherland… - American journal of …, 2018 - atsjournals.org
Rationale: Contacts of patients with tuberculosis (TB) constitute an important target
population for preventive measures because they are at high risk of infection with …

[HTML][HTML] Aerosol delivery, but not intramuscular injection, of adenovirus-vectored tuberculosis vaccine induces respiratory-mucosal immunity in humans

M Jeyanathan, DK Fritz, S Afkhami, E Aguirre… - JCI insight, 2022 - ncbi.nlm.nih.gov
Background Adenovirus-vectored (Ad-vectored) vaccines are typically administered via im
injection to humans and are incapable of inducing respiratory mucosal immunity. However …

The status of tuberculosis vaccine development

LK Schrager, J Vekemens, N Drager… - The Lancet Infectious …, 2020 - thelancet.com
Tuberculosis represents the leading global cause of death from an infectious agent.
Controlling the tuberculosis epidemic thus represents an urgent global public health priority …

The tuberculous granuloma and preexisting immunity

SB Cohen, BH Gern, KB Urdahl - Annual review of immunology, 2022 - annualreviews.org
Pulmonary granulomas are widely considered the epicenters of the immune response to
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Recent animal …

Tuberculosis in children

CM Perez-Velez, BJ Marais - New England Journal of Medicine, 2012 - Mass Medical Soc
Tuberculosis in Children | New England Journal of Medicine Skip to main content The New
England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …