Traditional research methodologies in the human respiratory system have always been
challenging due to their invasive nature. Recent advances in medical imaging and …

Many studies suggest limited effectiveness of spray devices for nasal drug delivery due
primarily to high deposition and clearance at the front of the nose. Here, nasal spray …

Experimental images from particle/droplet image analyser (PDIA) and particle image
velocimetry (PIV) imaging techniques of particle formation from a nasal spray device were …

This paper summarises current studies related to numerical gas-particle flows in the human
nasal cavity. Of interest are the numerical modelling requirements to consider the effects of …

This book presents a road map for applying the stages in conceptualization, evaluation, and
testing of biomedical devices in a systematic order of approach, leading to solutions for …

Three dimensional computational models of both sides of human nasal passages were
developed to investigate the effect of septal deviation on the flow patterns and deposition of …

Computational fluid dynamics (CFD) simulations of nasal drug delivery often neglect the
initial spray particle conditions (eg, particle velocity) and instead introduce particles …

This research investigated the impact of the full range of in vitro spray characterization tests
described in the FDA Draft Bioequivalence Guidance on nasal deposition pattern …

The nasal route presents an enormous opportunity to exploit the highly vascularized
respiratory airway for systemic drug delivery to provide more rapid onset of therapy and …

A sound understanding of the physics of multiphase flow is important for studying biofluid
dynamics in human, and the air flow in the respiratory system and blood flow in the …