Fibroblast growth factor (FGF) signalling via FGF receptors (FGFR1–4) orchestrates fetal
development and contributes to tissue and whole-body homeostasis, but can also promote …

The α-Klotho protein (hereafter Klotho) is an obligate coreceptor for fibroblast growth factor
23 (FGF23). It is produced in the kidneys, brain and other sites. Klotho insufficiency causes …

Basic fibroblast growth factor (bFGF) has proved to be effective for wound healing, yet its
effectiveness is extremely retarded in diabetic wounds due to the severe oxidative stress in …

As the body's defense mechanism against damage and infection, the inflammatory response
is a pathological process that involves a range of inflammatory cells and cytokines. A healthy …

Fibroblast growth factor 21 (FGF21) plays a vital role in normal eukaryotic organism
development and homeostatic metabolism under the influence of internal and external …

Abstract α-Klotho (KLA) is a type-1 membranous protein that can associate with fibroblast
growth factor receptor (FGFR) to form co-receptor for FGF23. The ectodomain of …

Fibroblasts, which originate from embryonic mesenchymal cells, are the predominant cell
type seen in loose connective tissue. As the main components of the internal environment …

Heterodimerization in RTKs is of vital importance in the RTK signaling and cell functions.
Heterodimerization between RTKs can result in diversity of downstream signals, increasing …

Exercise can regulate the immune function, activate the activity of immune cells, and
promote the health of the organism, but the mechanism is not clear. Skeletal muscle is a …

As our understanding of biological systems grows, so does the need to selectively target
individual or multiple members of specific protein families in order to probe their function …