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[HTML][HTML] Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
Diffraction (X-ray, neutron and electron) and electron cryo-microscopy are powerful methods
to determine three-dimensional macromolecular structures, which are required to …
to determine three-dimensional macromolecular structures, which are required to …
[HTML][HTML] Concepts and core principles of fragment-based drug design
In this review, a general introduction to fragment-based drug design and the underlying
concepts is given. General considerations and methodologies ranging from library …
concepts is given. General considerations and methodologies ranging from library …
Generalized biomolecular modeling and design with RoseTTAFold All-Atom
Deep-learning methods have revolutionized protein structure prediction and design but are
presently limited to protein-only systems. We describe RoseTTAFold All-Atom (RFAA), which …
presently limited to protein-only systems. We describe RoseTTAFold All-Atom (RFAA), which …
Fanzor is a eukaryotic programmable RNA-guided endonuclease
RNA-guided systems, which use complementarity between a guide RNA and target nucleic
acid sequences for recognition of genetic elements, have a central role in biological …
acid sequences for recognition of genetic elements, have a central role in biological …
Cryo-EM structures of the active NLRP3 inflammasome disc
Inflammasomes are cytosolic innate immune complexes that activate caspase-1 following
detection of pathogenic and endogenous dangers,,,–, and NACHT-, leucine-rich repeat …
detection of pathogenic and endogenous dangers,,,–, and NACHT-, leucine-rich repeat …
An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance
The Hippo pathway is a key growth control pathway that is conserved across species. The
downstream effectors of the Hippo pathway, YAP (Yes-associated protein) and TAZ …
downstream effectors of the Hippo pathway, YAP (Yes-associated protein) and TAZ …
Design of protein-binding proteins from the target structure alone
The design of proteins that bind to a specific site on the surface of a target protein using no
information other than the three-dimensional structure of the target remains a challenge …
information other than the three-dimensional structure of the target remains a challenge …
De novo design of protein interactions with learned surface fingerprints
Physical interactions between proteins are essential for most biological processes
governing life. However, the molecular determinants of such interactions have been …
governing life. However, the molecular determinants of such interactions have been …
[HTML][HTML] Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2
Summary The coronavirus disease 2019 (COVID-19) pandemic continues worldwide with
many variants arising, some of which are variants of concern (VOCs). A recent VOC, omicron …
many variants arising, some of which are variants of concern (VOCs). A recent VOC, omicron …
Virological characteristics of the SARS-CoV-2 Omicron BA. 2 subvariants, including BA. 4 and BA. 5
After the global spread of the SARS-CoV-2 Omicron BA. 2, some BA. 2 subvariants,
including BA. 2.9. 1, BA. 2.11, BA. 2.12. 1, BA. 4, and BA. 5, emerged in multiple countries …
including BA. 2.9. 1, BA. 2.11, BA. 2.12. 1, BA. 4, and BA. 5, emerged in multiple countries …