Quercetin: an effective polyphenol in alleviating diabetes and diabetic complications

L Yan, M Vaghari-Tabari, F Malakoti… - Critical reviews in …, 2023‏ - Taylor & Francis
Various studies, especially in recent years, have shown that quercetin has beneficial
therapeutic effects in various human diseases, including diabetes. Quercetin has significant …

Exosome-cargoed microRNAs: Potential therapeutic molecules for diabetic wound healing

R Lou, J Chen, F Zhou, C Wang, CH Leung, L Lin - Drug discovery today, 2022‏ - Elsevier
Highlights•Exosomal microRNAs are pivotal regulators of angiogenesis during wound
healing.•Exosomal microRNAs regulate VEGF expression and downstream signaling …

[HTML][HTML] miRNAs as biomarkers in diabetes: moving towards precision medicine

MA Angelescu, O Andronic, SO Dima… - International Journal of …, 2022‏ - mdpi.com
Diabetes mellitus (DM) is a complex metabolic disease with many specifically related
complications. Early diagnosis of this disease could prevent the progression to overt disease …

Peptide RL-QN15 promotes wound healing of diabetic foot ulcers through p38 mitogen-activated protein kinase and smad3/miR-4482-3p/vascular endothelial growth …

D Sun, K Guo, N Liu, Y Li, Y Li, Y Hu, S Li, Z Fu… - Burns & …, 2023‏ - academic.oup.com
Background Wound management of diabetic foot ulcers (DFUs) is a complex and
challenging task, and existing strategies fail to meet clinical needs. Therefore, it is important …

Adipose mesenchymal stem cell exosomes promote wound healing through accelerated keratinocyte migration and proliferation by activating the AKT/HIF-1α axis

Y Zhang, F Han, L Gu, P Ji, X Yang, M Liu… - Journal of Molecular …, 2020‏ - Springer
Accelerating wound healing is a key consideration for surgeons. The three stages of wound
healing include the inflammatory response, cell proliferation and tissue repair, and much …

[HTML][HTML] The regulatory functions of circular RNAs in osteosarcoma

N Soghli, D Qujeq, T Yousefi, N Soghli - Genomics, 2020‏ - Elsevier
Osteosarcoma (OS) is known as a malignant bone tumor affecting mainly children and
younger adults. Despite all the improvements in the treatment of OS, the overall survival …

Impact of Psychological Distress on Physiological Indicators of Healing Prognosis in Patients with Chronic Diabetic Foot Ulcers: A Longitudinal Study

J Da Silva, D Santos, M Vilaça, A Carvalho… - Advances in Wound …, 2024‏ - liebertpub.com
Objective: Diabetic foot ulcers (DFUs) are devastating complications of diabetes,
responsible for a high number of amputations worldwide. Due to its impact on chronic …

Increased expression of miR-155 in peripheral blood and wound margin tissue of type 2 diabetes mellitus patients associated with diabetic foot ulcer

M Xu, Y Li, Y Tang, X Zhao, D **e… - … Metabolic Syndrome and …, 2022‏ - Taylor & Francis
Purpose To investigate the correlations of miR-155 expression in the peripheral blood and
wound margin tissue of patients with diabetic foot ulcer (DFU) and explore the clinical value …

Accelerated wound healing in diabetic rat by miRNA-185-5p and its anti-inflammatory activity

KX Wang, LL Zhao, LT Zheng, LB Meng… - Diabetes, Metabolic …, 2023‏ - Taylor & Francis
Aim Addressing both inflammation and epithelialization during the treatment of diabetic foot
ulcers is an important step, but current treatment options are limited. MiRNA has important …

Downregulation of hsa-miR-203 in peripheral blood and wound margin tissue by negative pressure wound therapy contributes to wound healing of diabetic foot ulcers

L Liu, R Chen, Z Jia, X Li, Y Tang, X Zhao… - Microvascular …, 2022‏ - Elsevier
Negative pressure wound therapy (NPWT) has been widely used in the treatment of chronic
wounds, including diabetic foot ulcers (DFU) as the severe manifestation of diabetic foot …