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Microenvironment-driven metabolic adaptations guiding CD8+ T cell anti-tumor immunity
J Park, PC Hsueh, Z Li, PC Ho - Immunity, 2023 - cell.com
The metabolic stress occurring in the tumor microenvironment (TME) hampers T cell anti-
tumor immunity by disturbing T cell metabolic and epigenetic programs. Recent studies are …
tumor immunity by disturbing T cell metabolic and epigenetic programs. Recent studies are …
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy
Metabolic programming in the tumor microenvironment (TME) alters tumor immunity and
immunotherapeutic response in tumor-bearing mice and patients with cancer. Here, we …
immunotherapeutic response in tumor-bearing mice and patients with cancer. Here, we …
Metabolic challenges and interventions in CAR T cell therapy
Chimeric antigen receptor (CAR) T cells have achieved true clinical success in treating
hematological malignancy patients, laying the foundation of CAR T cells as a new pillar of …
hematological malignancy patients, laying the foundation of CAR T cells as a new pillar of …
T cell dysfunction and therapeutic intervention in cancer
Recent advances in immunotherapy have affirmed the curative potential of T cell-based
approaches for treating relapsed and refractory cancers. However, the therapeutic efficacy is …
approaches for treating relapsed and refractory cancers. However, the therapeutic efficacy is …
Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness
The accumulation of acidic metabolic waste products within the tumor microenvironment
inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it remains …
inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it remains …
Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation
X Si, M Shao, X Teng, Y Huang, Y Meng, L Wu, J Wei… - Cell Metabolism, 2024 - cell.com
The efficacy of chimeric antigen receptor (CAR) T cell therapy is hampered by relapse in
hematologic malignancies and by hyporesponsiveness in solid tumors. Long-lived memory …
hematologic malignancies and by hyporesponsiveness in solid tumors. Long-lived memory …
Mitochondrial heterogeneity in diseases
As key organelles involved in cellular metabolism, mitochondria frequently undergo
adaptive changes in morphology, components and functions in response to various …
adaptive changes in morphology, components and functions in response to various …
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment
Lineage transitions are a central feature of prostate development, tumourigenesis and
treatment resistance. While epigenetic changes are well known to drive prostate lineage …
treatment resistance. While epigenetic changes are well known to drive prostate lineage …
[HTML][HTML] Metabolism and epigenetics at the heart of T cell function
T cell subsets adapt and rewire their metabolism according to their functions and
surrounding microenvironment. Whereas naive T cells rely on mitochondrial metabolic …
surrounding microenvironment. Whereas naive T cells rely on mitochondrial metabolic …
Neoantigen-targeted TCR-engineered T cell immunotherapy: current advances and challenges
Adoptive cell therapy using T cell receptor-engineered T cells (TCR-T) is a promising
approach for cancer therapy with an expectation of no significant side effects. In the human …
approach for cancer therapy with an expectation of no significant side effects. In the human …