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[HTML][HTML] Base editing screens define the genetic landscape of cancer drug resistance mechanisms
Drug resistance is a principal limitation to the long-term efficacy of cancer therapies. Cancer
genome sequencing can retrospectively delineate the genetic basis of drug resistance, but …
genome sequencing can retrospectively delineate the genetic basis of drug resistance, but …
[HTML][HTML] Sensitivity and resistance of MET exon 14 mutations in lung cancer to eight MET tyrosine kinase inhibitors in vitro
Background MNNG HOS transforming gene (MET) exon 14 mutations in lung cancer,
including exon 14 skip** and point mutations, have been attracting the attention of …
including exon 14 skip** and point mutations, have been attracting the attention of …
From phenotypic hit to chemical probe: chemical biology approaches to elucidate small molecule action in complex biological systems
Biologically active small molecules have a central role in drug development, and as
chemical probes and tool compounds to perturb and elucidate biological processes. Small …
chemical probes and tool compounds to perturb and elucidate biological processes. Small …
Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastoma
High-risk neuroblastoma is often distinguished by amplification of MYCN and loss of
differentiation potential. We performed high-throughput drug screening of epigenetic …
differentiation potential. We performed high-throughput drug screening of epigenetic …
The pursuit of therapeutic biomarkers with high-throughput cancer cell drug screens
In the last decade we have witnessed tremendous advances in our understanding of the
landscape of the molecular alterations that underpin many of the most prevalent cancers, in …
landscape of the molecular alterations that underpin many of the most prevalent cancers, in …
Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania
Current genome-wide screens allow system-wide study of drug resistance but detecting
small nucleotide variants (SNVs) is challenging. Here, we use chemical mutagenesis, drug …
small nucleotide variants (SNVs) is challenging. Here, we use chemical mutagenesis, drug …
Diagnostic value of MiR-125b as a potential biomarker for stage I lung adenocarcinoma
Background: We aimed at exploring biological functions of differentially expressed miRNAs
during carcinogenesis, to identify miRNAs dysegulations involved in DNA repair …
during carcinogenesis, to identify miRNAs dysegulations involved in DNA repair …
[HTML][HTML] Identification of mutation accumulation as resistance mechanism emerging in first-line osimertinib treatment
Introduction The survival of patients with EGFR mutation-positive lung cancer has
dramatically improved since the introduction of EGFR tyrosine kinase inhibitors (EGFR …
dramatically improved since the introduction of EGFR tyrosine kinase inhibitors (EGFR …
A fifteen‐gene classifier to predict neoadjuvant chemotherapy responses in patients with stage IB to IIB squamous cervical cancer
X Tian, X Wang, Z Cui, J Liu, X Huang, C Shi… - Advanced …, 2021 - Wiley Online Library
Neoadjuvant chemotherapy (NACT) remains an attractive alternative for controlling locally
advanced cervical cancer. However, approximately 15–34% of women do not respond to …
advanced cervical cancer. However, approximately 15–34% of women do not respond to …
Pathway-based dissection of the genomic heterogeneity of cancer hallmarks' acquisition with SLAPenrich
Cancer hallmarks are evolutionary traits required by a tumour to develop. While extensively
characterised, the way these traits are achieved through the accumulation of somatic …
characterised, the way these traits are achieved through the accumulation of somatic …