Nucleotides are the foundational elements of life. Proliferative cells acquire nutrients for
energy production and the synthesis of macromolecules, including proteins, lipids, and …

Amino acid metabolism plays a pivotal role in tumor microenvironment, influencing various
aspects of cancer progression. The metabolic reprogramming of amino acids in tumor cells …

Summary Mitochondrial 10-formyltetrahydrofolate (10-formyl-THF) is utilized by three
mitochondrial enzymes to produce formate for nucleotide synthesis, NADPH for antioxidant …

The facilitative GLUT1 and GLUT3 hexose transporters are expressed abundantly in
macrophages, but whether they have distinct functions remains unclear. We confirmed that …

Nucleotides are substrates for multiple anabolic pathways, most notably DNA and RNA
synthesis. Since nucleotide synthesis inhibitors began to be used for cancer therapy in the …

Most cancer-related deaths are caused by the metastases, which commonly develop at
multiple organ sites including the brain, bone, and lungs. Despite longstanding observations …

Cellular purines, particularly adenosine 5′-triphosphate (ATP), fuel many metabolic
reactions, but less is known about the direct effects of pyrimidines on cellular metabolism …

Cellular metabolites are ancient molecules with pleiotropic implications in health and
disease. Beyond their cognate roles, they have signaling functions as the ligands for specific …

Metabolic heterogeneity of tumor microenvironment (TME) is a hallmark of cancer and a big
barrier to cancer treatment. Cancer cells display diverse capacities to utilize alternative …

There is a short window during which the neonatal heart has the proliferative capacity to
completely repair damage, an ability that is lost in adulthood. Inducing proliferation in adult …