Recent advances in natural products from plants for treatment of liver diseases

A Zhang, H Sun, X Wang - European journal of medicinal chemistry, 2013 - Elsevier
Liver disease is any condition that may cause liver inflammation or tissue damage and
affects liver function. Natural products that are found in vegetables, fruits, plant extracts …

Mass spectrometry‐driven drug discovery for development of herbal medicine

A Zhang, H Sun, X Wang - Mass spectrometry reviews, 2018 - Wiley Online Library
Herbal medicine (HM) has made a major contribution to the drug discovery process with
regard to identifying products compounds. Currently, more attention has been focused on …

Novel applications of mass spectrometry‐based metabolomics in herbal medicines and its active ingredients: current evidence

XJ Wang, JL Ren, AH Zhang, H Sun… - Mass Spectrometry …, 2019 - Wiley Online Library
Current evidence shows that herbal medicines could be beneficial for the treatment of
various diseases. However, the complexities present in chemical compositions of herbal …

A comprehensive and system review for the pharmacological mechanism of action of rhein, an active anthraquinone ingredient

H Sun, G Luo, D Chen, Z **ang - Frontiers in pharmacology, 2016 - frontiersin.org
Rhein is a major medicinal ingredient isolated from several traditional Chinese medicines,
including Rheum palmatum L., Aloe barbadensis Miller, Cassia angustifolia Vahl., and …

Scoparone as a therapeutic drug in liver diseases: Pharmacology, pharmacokinetics and molecular mechanisms of action

Y Hui, X Wang, Z Yu, X Fan, B Cui, T Zhao… - Pharmacological …, 2020 - Elsevier
Scoparone is an active and efficious ingredient of herbal medicine Artemisia capillaris
Thunb, which has been used clinically in traditional Chinese medicine formula (eg Yin-Chen …

Screening techniques for the identification of bioactive compounds in natural products

Y Fu, J Luo, J Qin, M Yang - Journal of pharmaceutical and biomedical …, 2019 - Elsevier
Natural products (NPs) have a long history of clinical use and are rich source of bioactive
compounds. The development of tools and techniques for identifying and analyzing NP …

[HTML][HTML] Metabolomics coupled with proteomics advancing drug discovery toward more agile development of targeted combination therapies

X Wang, A Zhang, P Wang, H Sun, G Wu, W Sun… - Molecular & Cellular …, 2013 - Elsevier
To enhance the therapeutic efficacy and reduce the adverse effects of traditional Chinese
medicine, practitioners often prescribe combinations of plant species and/or minerals, called …

Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases

JH Lee, SY Chiang, D Nam, WS Chung, J Lee, YS Na… - Cancer letters, 2014 - Elsevier
Signal transducers and activators of transcription (STAT)-3 is a latent cytosolic transcription
factor that has been closely associated with survival, proliferation, chemoresistance, and …

Functional metabolomics discover pentose and glucuronate interconversion pathways as promising targets for Yang Huang syndrome treatment with Yinchenhao …

H Sun, A Zhang, Q Song, H Fang, X Liu, J Su, L Yang… - RSC …, 2018 - pubs.rsc.org
Yinchenhao Tang (YCHT), a classic traditional Chinese medicine (TCM) formulae, plays an
important role in the treatment of Yang Huang syndrome (YHS). With the emergence of new …

Potentiating therapeutic effects by enhancing synergism based on active constituents from traditional medicine

A Zhang, H Sun, X Wang - Phytotherapy Research, 2014 - Wiley Online Library
Shifting current drug discovery tide from 'finding new drugs' to 'screening natural products'
may be helpful for overcoming the 'more investment, fewer drugs' challenge. Traditional …