Epidemiological studies have found that transportation noise increases the risk of
cardiovascular morbidity and mortality, with high-quality evidence for ischaemic heart …

Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Transportation noise is a ubiquitous urban exposure. In 2018, the World Health Organization
concluded that chronic exposure to road traffic noise is a risk factor for ischemic heart …

Background: Right ventricular (RV) function is the major determinant for both functional
capacity and survival in patients with pulmonary arterial hypertension (PAH). Despite the …

Aging is associated with a progressive decline in cardiovascular structure and function.
Accumulating evidence links cardiovascular aging to epigenetic alterations encompassing a …

Vast parts of mammalian genomes encode for transcripts that are not further translated into
proteins. The purpose of the majority of such noncoding ribonucleic acids (RNAs) remained …

Endothelial cells are, by number, one of the most abundant cell types in the heart and active
players in cardiac physiology and pathology. Coronary angiogenesis plays a vital role in …

Background: Biochemical DNA modification resembles a crucial regulatory layer among
genetic information, environmental factors, and the transcriptome. To identify epigenetic …

Obesity is defined as excessive body fat accumulation, and worldwide obesity has nearly
tripled since 1975. Excess of free fatty acids (FFAs) and triglycerides in obese individuals …

Soon after birth, the regenerative capacity of the mammalian heart is lost, cardiomyocytes
withdraw from the cell cycle and demonstrate a minimal proliferation rate. Despite improved …